Evidence map›Paper›PMID 39066181›Full record

ReviewViruses2024

Local Power: The Role of Tissue-Resident Immunity in Human Genital Herpes Simplex Virus Reactivation.

Jia Zhu, Maurine D Miner

Abstract readReview
In one paragraph

Review in Viruses, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Jia ZhuDepartment of Laboratory Medicine and Pathology, University of Washington, Seattle, WA 98109, USA.ORCID 0000-0002-8676-5105
Maurine D MinerVaccine and Infectious Disease Division, Fred Hutchinson Cancer Center, Seattle, WA 98109, USA.

Funding

Modeling of human HSV infection: development of immune-competent 3D skin-on-chip with vascular perfusionR01AI143773 · NIAID · UNIVERSITY OF WASHINGTON · PI ZHU, JIA · 2020 to 2024
$2.7M
Biofabricated 3-D skin model for antiviral drug discovery against human HSV infectionU18TR003208 · NCATS · UNIVERSITY OF WASHINGTON · PI ZHU, JIA · 2020 to 2021
$1.0M
NCATS NIH HHS U18 TR003208NIAID NIH HHS R01 AI143773
6 · The paper itself

Abstract

From established latency, human herpes virus type 2 (HSV-2) frequently reactivates into the genital tract, resulting in symptomatic ulcers or subclinical shedding. Tissue-resident memory (T

Indexed as

CD8-Positive T-LymphocytesHerpes GenitalisHerpesvirus 2, HumanVirus ActivationVirus LatencyAdaptive ImmunityAnimalsHumansImmunity, InnateImmunologic MemorySkinCD8+ T cellsdermal–epidermal junction (DEJ)genital herpesherpes simplex virus (HSV)HSV-2subclinical sheddingT cell receptor (TCR) repertoiretissue microenvironmenttissue-resident memory (TRM) T cells

Identifiers

PMID39066181
PMCPMC11281577

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.