Evidence map›Paper›PMID 39066176›Full record

ArticleViruses2024

Molecular Genotyping of Circulating Enterovirus in the Lazio Region from 2012 to 2023.

Martina Rueca, Francesco Vairo, Martina Spaziante, Lavinia Fabeni, Federica Forbici, Giulia Berno, Cesare Ernesto Maria Gruber, Simonetta Picone, Camilla Ajassa, Enrico Girardi and 2 more

Abstract read
In one paragraph

Article in Viruses, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Martina RuecaLaboratory of Virology, National Institute for Infectious Diseases "Lazzaro Spallanzani" IRCCS, 00149 Rome, Italy.ORCID 0000-0001-5162-046X
Francesco VairoRegional Service for Surveillance and Control of Infectious Diseases (SERESMI)-Lazio Region, National Institute for Infectious Diseases "Lazzaro Spallanzani" IRCCS, 00149 Rome, Italy.
Martina SpazianteRegional Service for Surveillance and Control of Infectious Diseases (SERESMI)-Lazio Region, National Institute for Infectious Diseases "Lazzaro Spallanzani" IRCCS, 00149 Rome, Italy.
Lavinia FabeniLaboratory of Virology, National Institute for Infectious Diseases "Lazzaro Spallanzani" IRCCS, 00149 Rome, Italy.
Federica ForbiciLaboratory of Virology, National Institute for Infectious Diseases "Lazzaro Spallanzani" IRCCS, 00149 Rome, Italy.
Giulia BernoLaboratory of Virology, National Institute for Infectious Diseases "Lazzaro Spallanzani" IRCCS, 00149 Rome, Italy.
Cesare Ernesto Maria GruberLaboratory of Virology, National Institute for Infectious Diseases "Lazzaro Spallanzani" IRCCS, 00149 Rome, Italy.ORCID 0000-0002-8831-3380
Simonetta PiconeNeonatology and Neonatal Intensive Care Unit, Policlinico Casilino, 00169 Rome, Italy.
Camilla AjassaDepartment of Public Health and Infectious Diseases, Sapienza University Hospital "Policlinico Umberto I", 00161 Rome, Italy.
Enrico GirardiScientific Direction, National Institute for Infectious Diseases "Lazzaro Spallanzani" IRCCS, 00149 Rome, Italy.ORCID 0000-0001-8182-5896
Fabrizio MaggiLaboratory of Virology, National Institute for Infectious Diseases "Lazzaro Spallanzani" IRCCS, 00149 Rome, Italy.ORCID 0000-0001-7489-5271
Maria Beatrice ValliLaboratory of Virology, National Institute for Infectious Diseases "Lazzaro Spallanzani" IRCCS, 00149 Rome, Italy.ORCID 0000-0001-5022-5388

Funding

Ministero della Salute Ricerca Corrente linea 1Ministero della Salute SG-2019-12370164
6 · The paper itself

Abstract

Enteroviruses (EVs) are ubiquitous viruses that circulate worldwide, causing sporadic or epidemic infections, typically during the summer and fall. They cause a broad spectrum of illnesses, ranging from an unspecified febrile clinical presentation to a severe illness. EVs are recognized to be the most frequent etiological agents of aseptic meningitis in children. However, as the infection is usually mild and self-limiting, it remains underestimated, and the epidemiology of EVs is poorly understood. To date, no vaccine or effective therapy for all types of enteroviruses is available, and EVs constitute a public health concern. Here, we investigated the molecular epidemiology of EV strains circulating in the Lazio region over a 10-year time span (2012-2023) by using a sequence-typing approach and phylogenetic analysis. The epidemiological trend of EV infection has undergone changes during the SARS-CoV-2 pandemic (2020-2021), which resulted in a modification in terms of the number of diagnosed cases and seasonality. From 2022, the circulation of EVs showed a behavior typical of the pre-pandemic period, although changes in predominantly circulating strains have been noted. Both epidemic and sporadic circulation events have been characterized in the Lazio region. Further analyses are needed to better characterize any strain with higher potential pathogenic power and to identify possible recombinant strains.

Indexed as

EnterovirusEnterovirus InfectionsGenotypeMolecular EpidemiologyPhylogenyChildCOVID-19HumansSARS-CoV-2Seasonsenterovirusenterovirus typingmolecular epidemiologyphylogenesissequencing

Identifiers

PMID39066176
PMCPMC11281471

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.