Evidence map›Paper›PMID 39066168›Full record

Observational studyViruses2024

Mismanagement of SARS-CoV-2 Infection Pre Hospitalisation during the Omicron Era: Antibiotics and Steroids Instead of Early Antivirals.

Andrea Giacomelli, Cosmin Lucian Ciubotariu, Martina Zacheo, Andrea Rabbione, Margherita Pieruzzi, Federico Barone, Andrea Poloni, Giacomo Casalini, Giacomo Pozza, Marta Colaneri and 6 more

Abstract readObservational Study
In one paragraph

Observational study in Viruses, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Andrea GiacomelliDepartment of Biomedical and Clinical Sciences (DIBIC), Università degli Studi di Milano, Via G.B. Grassi 74, 20157 Milan, Italy.ORCID 0000-0003-3685-4289
Cosmin Lucian CiubotariuDepartment of Biomedical and Clinical Sciences (DIBIC), Università degli Studi di Milano, Via G.B. Grassi 74, 20157 Milan, Italy.ORCID 0009-0003-3607-1847
Martina ZacheoDepartment of Biomedical and Clinical Sciences (DIBIC), Università degli Studi di Milano, Via G.B. Grassi 74, 20157 Milan, Italy.
Andrea RabbioneDepartment of Biomedical and Clinical Sciences (DIBIC), Università degli Studi di Milano, Via G.B. Grassi 74, 20157 Milan, Italy.
Margherita PieruzziDepartment of Biomedical and Clinical Sciences (DIBIC), Università degli Studi di Milano, Via G.B. Grassi 74, 20157 Milan, Italy.
Federico BaroneDepartment of Biomedical and Clinical Sciences (DIBIC), Università degli Studi di Milano, Via G.B. Grassi 74, 20157 Milan, Italy.
Andrea PoloniDepartment of Biomedical and Clinical Sciences (DIBIC), Università degli Studi di Milano, Via G.B. Grassi 74, 20157 Milan, Italy.ORCID 0000-0002-6765-8101
Giacomo CasaliniIII Division of Infectious Diseases, ASST Fatebenefratelli Sacco, Luigi Sacco Hospital, 20157 Milan, Italy.ORCID 0000-0003-0740-5361
Giacomo PozzaDepartment of Biomedical and Clinical Sciences (DIBIC), Università degli Studi di Milano, Via G.B. Grassi 74, 20157 Milan, Italy.
Marta ColaneriII Infectious Diseases Unit, Ospedale Luigi Sacco, ASST Fatebenefratelli Sacco, 20157 Milan, Italy.ORCID 0000-0002-5939-9576
Matteo PasseriniII Infectious Diseases Unit, Ospedale Luigi Sacco, ASST Fatebenefratelli Sacco, 20157 Milan, Italy.
Anna Lisa RidolfoIII Division of Infectious Diseases, ASST Fatebenefratelli Sacco, Luigi Sacco Hospital, 20157 Milan, Italy.ORCID 0000-0003-1106-6219
Cristina GervasoniDepartment of Biomedical and Clinical Sciences (DIBIC), Università degli Studi di Milano, Via G.B. Grassi 74, 20157 Milan, Italy.
Dario CattaneoGestione Ambulatoriale Politerapie Outpatient Clinic, ASST Fatebenefratelli Sacco University Hospital, 20154 Milan, Italy.ORCID 0000-0003-1512-6530
Andrea GoriDepartment of Biomedical and Clinical Sciences (DIBIC), Università degli Studi di Milano, Via G.B. Grassi 74, 20157 Milan, Italy.ORCID 0000-0001-6587-4794
Spinello AntinoriDepartment of Biomedical and Clinical Sciences (DIBIC), Università degli Studi di Milano, Via G.B. Grassi 74, 20157 Milan, Italy.ORCID 0000-0003-0569-9407

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The aim of this study was to assess the prevalence of inappropriate treatment among hospitalised patients affected by SARS-CoV-2 infection before hospital admission during the Omicron era. This single-centre, retrospective observational study included all the patients hospitalised because of SARS-CoV-2 infection during three periods characterised by the Italian prevalence of an Omicron variant of concern: (1) January-May 2022 (BA.1-BA.2), (2) June-October 2022 (BA.5), and (3) November 2022-March 2023 (BQ.1-XBB). Inappropriate treatment was defined as pre-hospitalisation exposure to antibiotics and/or steroids in the absence of a documented bacterial infection or the need for steroid treatment of an underlying medical condition. A total of 931 subjects were hospitalised: 394 in period 1, 334 in period 2, and 203 in period 3. Of the 157 patients undergoing inappropriate treatment (16.9%), 142 (15.3%) received antibiotics and 52 (5.6%) steroids. The proportion of inappropriately treated patients significantly decreased over time, from 23.1% in period 1 to 11.7% in period 2 and 13.3% in period 3 (

Indexed as

Anti-Bacterial AgentsAntiviral AgentsCOVID-19COVID-19 Drug TreatmentHospitalizationSARS-CoV-2SteroidsAdultAgedAged, 80 and overFemaleHumansItalyMaleMiddle AgedRetrospective StudiesAnti-Bacterial AgentsAntiviral AgentsSteroidsantibioticsCOVID-19inappropriate treatmentnirmatrelvir/ritonavirOmicronsteroids

Identifiers

PMID39066168
PMCPMC11281468

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.