Evidence map›Paper›PMID 39065820›Full record

ArticlePharmaceuticals (Basel, Switzerland)2024

Sika Deer Velvet Antler Peptide Exerts Neuroprotective Effect in a Parkinson's Disease Model via Regulating Oxidative Damage and Gut Microbiota.

Ying Liu, Hongyuan Li, Min Yang, Jia Guo, Zepeng Sun, Shuyue Wang, Ru Li, Xin Pang, Yumi Kim, Xiaohui Wang and 1 more

Abstract read
In one paragraph

Article in Pharmaceuticals (Basel, Switzerland), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
  2. Review
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  5. Article
  6. Review
  7. Optimizing protein yield from growing deer antlers.Frontiers in bioengineering and biotechnology · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Ying LiuInstitute of Special Animal and Plant Sciences, Chinese Academy of Agricultural Sciences, Changchun 130112, China.
Hongyuan LiLaboratory of Chemistry Biology, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, China.
Min YangInstitute of Special Animal and Plant Sciences, Chinese Academy of Agricultural Sciences, Changchun 130112, China.
Jia GuoInstitute of Special Animal and Plant Sciences, Chinese Academy of Agricultural Sciences, Changchun 130112, China.
Zepeng SunInstitute of Special Animal and Plant Sciences, Chinese Academy of Agricultural Sciences, Changchun 130112, China.
Shuyue WangSchool of Chemistry and Life Science, Changchun University of Technology, Changchun 130012, China.
Ru LiInstitute of Special Animal and Plant Sciences, Chinese Academy of Agricultural Sciences, Changchun 130112, China.
Xin PangInstitute of Special Animal and Plant Sciences, Chinese Academy of Agricultural Sciences, Changchun 130112, China.
Yumi KimDepartment of Biomedical Engineering, Ulsan National Institute of Science and Technology (UNIST), Ulsan 44919, Republic of Korea.
Xiaohui WangLaboratory of Chemistry Biology, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, China.ORCID 0000-0002-3415-5612
Yinghua PengInstitute of Special Animal and Plant Sciences, Chinese Academy of Agricultural Sciences, Changchun 130112, China.ORCID 0000-0003-0835-8317

Funding

Jilin Province Science and Technology Development Plant Project YDZJ202201ZYTS465the Chinese Academy of Sciences Pioneer Hundred Talents Program and the Science and Tech-nology Innovation Program of the Chinese Academy of Agricultural Sciences CAAS-ASTIP-2021-ISAPSthe Korea Evaluation Institute of Industrial Technology (KEIT) with funding from the Ministry of Trade, Industry and Energy in 2023 20023198
6 · The paper itself

Abstract

Parkinson's disease (PD) is the second most common neurodegenerative disorder globally. Recognizing the potential of velvet antler in the nervous system, as shown in numerous studies, this research was aimed at evaluating the neuroprotective effects of Sika Deer velvet antler peptide (VAP), along with the underlying mechanisms in neurotoxin-induced PD models. Initially, a peptidomic analysis of the VAP, which comprised 189 varieties of peptides, was conducted using LC-MS. Nine sequences were identified as significant using Proteome Discoverer 2.5 software. In a cellular model of PD, where PC12 cells are treated with the neurotoxin 1-methyl-4-phenylpyridinium (MPP

Indexed as

gut microbiotaneuroprotectionoxidative stressParkinson’s diseasepeptidevelvet antler

Identifiers

PMID39065820
PMCPMC11280472

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.