ArticlePharmaceuticals (Basel, Switzerland)2024
Synthesis of Nitrostyrylthiazolidine-2,4-dione Derivatives Displaying Antileishmanial Potential.
Omar Khoumeri, Sébastien Hutter, Nicolas Primas, Caroline Castera-Ducros, Sandra Carvalho, Susan Wyllie, Mohamed Lotfi Efrit, Dimitri Fayolle, Marc Since, Patrice Vanelle and 3 more
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In one paragraphArticle in Pharmaceuticals (Basel, Switzerland), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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5 · Who and what moneyAuthors and funding
13 authors.
Omar KhoumeriTeam Pharmaco-Chimie Radicalaire, Faculté de Pharmacie, Aix Marseille University, CNRS, ICR UMR 7273, 27 Boulevard Jean Moulin, CS30064, CEDEX 05, 13385 Marseille, France.
Sébastien HutterIHU Méditerranée Infection, UMR RITMES, TEAM-VEPTE, Aix Marseille University, 19-21 Boulevard Jean Moulin, 13005 Marseille, France.
Nicolas PrimasTeam Pharmaco-Chimie Radicalaire, Faculté de Pharmacie, Aix Marseille University, CNRS, ICR UMR 7273, 27 Boulevard Jean Moulin, CS30064, CEDEX 05, 13385 Marseille, France.ORCID 0000-0002-6713-6039 Caroline Castera-DucrosTeam Pharmaco-Chimie Radicalaire, Faculté de Pharmacie, Aix Marseille University, CNRS, ICR UMR 7273, 27 Boulevard Jean Moulin, CS30064, CEDEX 05, 13385 Marseille, France.
Sandra CarvalhoWellcome Centre for Anti-Infectives Research, School of Life Sciences, University of Dundee, Dow Street, Dundee DD1 5EH, UK.ORCID 0000-0001-6695-1683 Susan WyllieWellcome Centre for Anti-Infectives Research, School of Life Sciences, University of Dundee, Dow Street, Dundee DD1 5EH, UK.ORCID 0000-0001-8810-5605 Mohamed Lotfi EfritLaboratoire de Synthèse Organique et Hétérocyclique Sélective-Evaluation D'activité Biologique, LR17ES01, Faculté des Sciences de Tunis, Université de Tunis El Manar, Campus Universitaire, Tunis 2092, Tunisia.ORCID 0000-0002-6950-0519 Dimitri FayolleNormandie Université, UNICAEN, CERMN, DruiD Platform, Boulevard Becquerel, 14000 Caen, France.
Marc SinceNormandie Université, UNICAEN, CERMN, DruiD Platform, Boulevard Becquerel, 14000 Caen, France.ORCID 0000-0003-3984-5812 Patrice VanelleTeam Pharmaco-Chimie Radicalaire, Faculté de Pharmacie, Aix Marseille University, CNRS, ICR UMR 7273, 27 Boulevard Jean Moulin, CS30064, CEDEX 05, 13385 Marseille, France.ORCID 0000-0002-9946-829X Pierre VerhaegheCNRS, Département de Pharmacochimie Moléculaire UMR 5063, University Grenoble Alpes, 38041 Grenoble, France.ORCID 0000-0003-0238-2447 Nadine AzasIHU Méditerranée Infection, UMR RITMES, TEAM-VEPTE, Aix Marseille University, 19-21 Boulevard Jean Moulin, 13005 Marseille, France.
Funding
Agence Universitaire de la Francophonie N/AWellcome Trust 203134/Z/16/Z
6 · The paper itselfAbstract
A series of 61 thiazolidine-2,4-diones bearing a styryl group at position 5 was synthesized in 2-5 steps and their structure was proved by elemental and spectral analyses. The compounds obtained were evaluated in vitro against the promastigote stage of the kinetoplastid parasite
Indexed as
L. infantumnitrostyryl moietythiazolidinedione ringvisceral leishmaniasis
Identifiers
PMID39065730
PMCPMC11280390
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