Evidence map›Paper›PMID 39065729›Full record

ArticlePharmaceuticals (Basel, Switzerland)2024

Extended Release of Bupivacaine from Temperature-Responsive PNDJ Hydrogels Improves Postoperative Weight-Bearing in Rabbits Following Knee Surgery.

Derek J Overstreet, Gabriel Zdrale, Alex C McLaren

Abstract read
In one paragraph

Article in Pharmaceuticals (Basel, Switzerland), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Derek J OverstreetSchool of Biological & Health Systems Engineering, Arizona State University, Tempe, AZ 85287, USA.ORCID 0000-0002-0306-1541
Gabriel ZdraleSonoran Biosciences, Tempe, AZ 85284, USA.
Alex C McLarenSchool of Biological & Health Systems Engineering, Arizona State University, Tempe, AZ 85287, USA.

Funding

Sustained-release gel for multi-day control of postoperative painR43GM145020 · NIGMS · SONORAN BIOSCIENCES, INC. · PI OVERSTREET, DEREK JAMES · 2022 to 2022
$260k
NIGMS NIH HHS R43 GM145020NIH HHS R43GM145020
6 · The paper itself

Abstract

Effective treatment of postoperative pain lasting for multiple days without opioids is an important clinical need. We previously reported analgesia lasting up to 96 h in a porcine soft tissue model of postoperative pain using SBG004, an extended-release formulation of bupivacaine based on the temperature-responsive polymer poly(

Indexed as

acute painextended releasehydrogelinjectablekneelocal anestheticnon-opioidorthopaedic surgerypostoperative pain

Identifiers

PMID39065729
PMCPMC11280370

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.