Evidence map›Paper›PMID 39065722›Full record

ArticlePharmaceuticals (Basel, Switzerland)2024

Solid-State NMR Characterization of Mefloquine Resinate Complexes Designed for Taste-Masking Pediatric Formulations.

Leandro B Borré, Eduardo G R Sousa, Rosane A S San Gil, Mateus M Baptista, Alexandre A Leitão, João M A R De Almeida, Olívia Carr, Osvaldo N Oliveira, Flávio M Shimizu, Thiago F Guimarães

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pharmaceuticals (Basel, Switzerland), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Leandro B BorréInstituto de Química, Universidade Federal do Rio de Janeiro, Rio de Janeiro 21941-909, RJ, Brazil.
Eduardo G R SousaInstituto de Tecnologia em Fármacos (Farmanguinhos), Fundação Oswaldo Cruz, Rio de Janeiro 21041-250, RJ, Brazil.ORCID 0000-0003-4377-4834
Rosane A S San GilInstituto de Química, Universidade Federal do Rio de Janeiro, Rio de Janeiro 21941-909, RJ, Brazil.
Mateus M BaptistaInstituto de Química, Universidade Federal do Rio de Janeiro, Rio de Janeiro 21941-909, RJ, Brazil.
Alexandre A LeitãoDepartamento de Química, Universidade Federal de Juiz de Fora, Juiz de Fora 36036-900, MG, Brazil.ORCID 0000-0002-1439-486X
João M A R De AlmeidaInstituto de Química, Universidade Federal do Rio de Janeiro, Rio de Janeiro 21941-909, RJ, Brazil.ORCID 0000-0003-0272-4339
Olívia CarrSão Carlos Institute of Physics, University of São Paulo, São Carlos 13566-590, SP, Brazil.
Osvaldo N OliveiraSão Carlos Institute of Physics, University of São Paulo, São Carlos 13566-590, SP, Brazil.
Flávio M ShimizuDepartment of Applied Physics, Institute of Physics (IFGW), University of Campinas (UNICAMP), "Gleb Wataghin", Campinas 13083-970, SP, Brazil.ORCID 0000-0002-4833-9893
Thiago F GuimarãesInstituto de Tecnologia em Fármacos (Farmanguinhos), Fundação Oswaldo Cruz, Rio de Janeiro 21041-250, RJ, Brazil.ORCID 0000-0002-4534-6414

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Mefloquine (MQ) is an antimalarial medication prescribed to treat or malaria prevention.. When taken by children, vomiting usually occurs, and new doses of medication frequently need to be taken. So, developing pediatric medicines using taste-masked antimalarial drug complexes is mandatory for the success of mefloquine administration. The hypothesis that binding mefloquine to an ion-exchange resin (R) could circumvent the drug's bitter taste problem was proposed, and solid-state

Indexed as

13C NMRCPMAS NMRelectronic tongueion-exchange resinmefloquineT1ρH relaxation timetaste masking

Identifiers

PMID39065722
PMCPMC11280060

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.