Evidence map›Paper›PMID 39065706›Full record

ArticlePharmaceuticals (Basel, Switzerland)2024

Integrating Natural Deep Eutectic Solvents into Nanostructured Lipid Carriers: An Industrial Look.

Luísa Schuh, Luane Almeida Salgado, Tathyana Benetis Piau, Ariane Pandolfo Silveira, Caio Leal, Luís Felipe Romera, Marina Arantes Radicchi, Mac-Kedson Medeiros Salviano Santos, Leila Falcao, Cesar Koppe Grisolia and 4 more

Abstract read
In one paragraph

Article in Pharmaceuticals (Basel, Switzerland), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Review
  2. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Luísa SchuhCooil Cosmetics, Brasília 72622-401, DF, Brazil.ORCID 0009-0000-2009-2414
Luane Almeida SalgadoCooil Cosmetics, Brasília 72622-401, DF, Brazil.ORCID 0009-0003-0721-7050
Tathyana Benetis PiauLaboratory of Genetic Toxicology, Department of Genetics and Morphology, Institute of Biological Sciences, University of Brasília, Brasília 70910-900, DF, Brazil.ORCID 0009-0005-2936-2149
Ariane Pandolfo SilveiraCooil Cosmetics, Brasília 72622-401, DF, Brazil.ORCID 0000-0002-6350-0235
Caio LealCooil Cosmetics, Brasília 72622-401, DF, Brazil.ORCID 0009-0001-7308-8790
Luís Felipe RomeraCooil Cosmetics, Brasília 72622-401, DF, Brazil.ORCID 0009-0004-9031-3904
Marina Arantes RadicchiCooil Cosmetics, Brasília 72622-401, DF, Brazil.ORCID 0000-0001-9149-316X
Mac-Kedson Medeiros Salviano SantosGreen Nanotechnology Group, University of Brasília, Brasília 72220-900, DF, Brazil.
Leila FalcaoInaturals SAS, 2 Bis, Impasse Henri Mouret, 84000 Avignon, France.
Cesar Koppe GrisoliaLaboratory of Genetic Toxicology, Department of Genetics and Morphology, Institute of Biological Sciences, University of Brasília, Brasília 70910-900, DF, Brazil.ORCID 0000-0002-4456-1577
Eliana Fortes GrisFaculty of Ceilândia, University of Brasília, Brasília 72220-275, DF, Brazil.ORCID 0000-0003-0083-4075
Luis Alexandre MuehlmannFaculty of Ceilândia, University of Brasília, Brasília 72220-275, DF, Brazil.ORCID 0000-0003-4711-7583
Sônia Nair BáoLaboratory of Microscopy and Microanalysis, Department of Cell Biology, Institute of Biological Sciences, University of Brasília, Brasília 70910-900, DF, Brazil.ORCID 0000-0002-9873-3098
Victor Carlos MelloCooil Cosmetics, Brasília 72622-401, DF, Brazil.ORCID 0000-0003-4129-1839

Funding

FAP-DF/Brazil 00193-00002253/2023-66National Council for Scientific and Technological Development-CNPq 403033/2023-3
6 · The paper itself

Abstract

The industries are searching for greener alternatives for their productions due to the rising concern about the environment and creation of waste and by-products without industrial utility for that specific line of products. This investigation describes the development of two stable nanostructured lipid carriers (NLCs): one is the formulation of a standard NLC, and the other one is the same NLC formulation associated with a natural deep eutectic solvent (NaDES). The research presents the formulation paths of the NLCs through completeness, which encompass dynamic light scattering (DLS), zeta potential tests, and pH. Transmission electron microscopy (TEM) and confocal microscopy were performed to clarify the morphology. Cytotoxicity tests with zebrafish were realized, and the results are complementary to the in vitro outcomes reached with fibroblast L132 tests by the MTT technique and the zymography test. Infrared spectroscopy and X-ray diffractometry tests elucidated the link between the physicochemical characteristics of the formulation and its behavior and properties. Different cooling techniques were explored to prove the tailorable properties of the NLCs for any industrial applications. In conclusion, the compiled results show the successful formulation of new nanocarriers based on a sustainable, eco-friendly, and highly tailorable technology, which presents low cytotoxic potential.

Indexed as

green nanotechnologyNaDESNLC

Identifiers

PMID39065706
PMCPMC11280234

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.