Evidence map›Paper›PMID 39065648›Full record

ArticlePharmaceutics2024

Design of Novel TRPA1 Agonists Based on Structure of Natural Vasodilator Carvacrol-In Vitro and In Silico Studies.

Đorđe Đukanović, Relja Suručić, Milica Gajić Bojić, Saša M Trailović, Ranko Škrbić, Žarko Gagić

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pharmaceutics, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Đorđe ĐukanovićCentre for Biomedical Research, Faculty of Medicine, University of Banja Luka, 78000 Banja Luka, Bosnia and Herzegovina.
Relja SuručićDepartment of Pharmacy, Faculty of Medicine, University of Banja Luka, 78000 Banja Luka, Bosnia and Herzegovina.
Milica Gajić BojićCentre for Biomedical Research, Faculty of Medicine, University of Banja Luka, 78000 Banja Luka, Bosnia and Herzegovina.ORCID 0009-0006-8433-7808
Saša M TrailovićDepartment of Pharmacology and Toxicology, Faculty of Veterinary Medicine, University of Belgrade, 11000 Belgrade, Serbia.ORCID 0000-0002-2190-7985
Ranko ŠkrbićCentre for Biomedical Research, Faculty of Medicine, University of Banja Luka, 78000 Banja Luka, Bosnia and Herzegovina.ORCID 0000-0002-6643-1781
Žarko GagićDepartment of Pharmacy, Faculty of Medicine, University of Banja Luka, 78000 Banja Luka, Bosnia and Herzegovina.ORCID 0000-0001-9657-3150

Funding

Ministry of Scientific and Technological Development and Higher Education of Republic of Srpska 19.032/961-28/23.
6 · The paper itself

Abstract

Considering the escalating global prevalence and the huge therapeutic demand for the treatment of hypertension, there is a persistent need to identify novel target sites for vasodilator action. This study aimed to investigate the role of TRPA1 channels in carvacrol-induced vasodilation and to design novel compounds based on carvacrol structure with improved activities. In an isolated tissue bath experiment, it was shown that 1 µM of the selective TRPA1 antagonist A967079 significantly (

Indexed as

3D-QSARcarvacrolhypertensionmolecular dockingTRPA1

Identifiers

PMID39065648
PMCPMC11280049

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.