Evidence map›Paper›PMID 39065644›Full record

ArticlePharmaceutics2024

Enhanced Antibacterial Activity of Clindamycin Using Molecularly Imprinted Polymer Nanoparticles Loaded with Polyurethane Nanofibrous Scaffolds for the Treatment of Acne Vulgaris.

Sammar Fathy Elhabal, Rehab Abdelmonem, Rasha Mohamed El Nashar, Mohamed Fathi Mohamed Elrefai, Ahmed Mohsen Elsaid Hamdan, Nesreen A Safwat, Mai S Shoela, Fatma E Hassan, Amira Rizk, Soad L Kabil and 3 more

Abstract read
In one paragraph

Article in Pharmaceutics, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Sammar Fathy ElhabalDepartment of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Modern University for Technology and Information (MTI), Mokattam, Cairo 11571, Egypt.
Rehab AbdelmonemDepartment of Industrial Pharmacy, College of Pharmaceutical Sciences and Drug Manufacturing, Misr University for Science and Technology (MUST), 6th of October City 12566, Egypt.ORCID 0000-0002-2522-8082
Rasha Mohamed El NasharChemistry Department, Faculty of Science, Cairo University, Giza 12613, Egypt.ORCID 0000-0001-6150-8420
Mohamed Fathi Mohamed ElrefaiDepartment of Anatomy, Histology, Physiology and Biochemistry, Faculty of Medicine, The Hashemite University, Zarqa 13133, Jordan.
Ahmed Mohsen Elsaid HamdanDepartment of Pharmacy Practice, Faculty of Pharmacy, University of Tabuk, Tabuk 71491, Saudi Arabia.ORCID 0000-0003-4930-792X
Nesreen A SafwatDepartment of Microbiology and Immunology, Faculty of Pharmacy, Modern University for Technology and Information (MTI), Mokattam, Cairo 11571, Egypt.
Mai S ShoelaDepartment of Clinical Pharmacology, Faculty of Medicine, Alexandria University, Alexandria 21526, Egypt.
Fatma E HassanMedical Physiology Department, Faculty of Medicine, Cairo University, Giza 11562, Egypt.
Amira RizkFood Science and Technology Department, Faculty of Agricultural, Tanta University, Tanta City 31527, Egypt.
Soad L KabilDepartment of Clinical Pharmacology, Faculty of Medicine, Zagazig University, Zagazig 44519, Egypt.ORCID 0000-0002-7478-9732
Nagla Ahmed El-NabarawyNational Egyptian Center of Environmental & Toxicological Research (NECTR), Faculty of Medicine, Cairo University, Cairo 11562, Egypt.ORCID 0000-0003-4657-5777
Amal Anwar TahaDepartment of Pharmaceutics, College of Pharmaceutical Sciences and Drug Manufacturing, Misr University for Science and Technology (MUST), 6th of October City 12566, Egypt.ORCID 0000-0001-8477-4027
Mohamed El-NabarawiDepartment of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Cairo University, Cairo 11562, Egypt.ORCID 0000-0003-0070-1969

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Acne vulgaris, a prevalent skin condition, arises from an imbalance in skin flora, fostering bacterial overgrowth. Addressing this issue, clindamycin molecularly imprinted polymeric nanoparticles (Clin-MIP) loaded onto polyurethane nanofiber scaffolds were developed for acne treatment. Clin-MIP was synthesized via precipitation polymerization using methacrylic acid (MAA), ethylene glycol dimethacrylate (EGDMA), and azoisobutyronitrile (AIBN) as functional monomers, crosslinkers, and free-radical initiators, respectively. MIP characterization utilized Fourier-transform infrared spectroscopy (FTIR) and transmission electron microscopy (TEM) before being incorporated into polyurethane nanofibers through electrospinning. Further analysis involved FTIR, scanning electron microscopy (SEM), in vitro release studies, and an ex vivo study. Clin-MIP showed strong antibacterial activity against

Indexed as

acneantimicrobialclindamycininflammationmolecularly imprinted polymerpolyurethane nanofiberStaphylococcus aureus

Identifiers

PMID39065644
PMCPMC11279838

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.