Evidence map›Paper›PMID 39065549›Full record

ReviewPharmaceutics2024

Carrier Systems for Advanced Drug Delivery: Improving Drug Solubility/Bioavailability and Administration Routes.

Sonia Losada-Barreiro, Sumeyye Celik, Zerrin Sezgin-Bayindir, Sofía Bravo-Fernández, Carlos Bravo-Díaz

Abstract readReview
In one paragraph

Review in Pharmaceutics, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Sonia Losada-BarreiroDepartamento de Química-Física, Facultade de Química, Universidade de Vigo, 36200 Vigo, Pontevedra, Spain.ORCID 0000-0002-9447-5626
Sumeyye CelikDepartment of Pharmaceutical Technology, Faculty of Pharmacy, Ankara University, 06560 Ankara, Turkey.
Zerrin Sezgin-BayindirDepartment of Pharmaceutical Technology, Faculty of Pharmacy, Ankara University, 06560 Ankara, Turkey.ORCID 0000-0002-0386-7887
Sofía Bravo-FernándezDentistry Department, Primary Health Unit, Galician Health Service (SERGAS), Calle Mourin s/n, 15330 Ortigueira, A Coruña, Spain.
Carlos Bravo-DíazDepartamento de Química-Física, Facultade de Química, Universidade de Vigo, 36200 Vigo, Pontevedra, Spain.ORCID 0000-0002-9468-0881

Funding

MICIU/AEI/ 10.13039/501100011033 and "ERDF/EU" PID2022-136443OB-I00
6 · The paper itself

Abstract

The disadvantages of some conventional drugs, including their low bioavailability, poor targeting efficiency, and important side effects, have led to the rational design of drug delivery systems. In particular, the introduction of drug delivery systems is a potential approach to enhance the uptake of therapeutic agents and deliver them at the right time and in the right amount of concentration at the required site, as well as open new strategies for effective illness treatment. In this review, we provide a basic understanding of drug delivery systems with an emphasis on the use of cyclodextrin-, polymer- and surfactant-based delivery systems. These systems are very attractive because they are biocompatible and biodegradable nanomaterials with multifunctional components. We also provide some details on their design considerations and their use in a variety of medical applications by employing several routes of administration.

Indexed as

administration routesdrug bioavailabilitydrug delivery systemsdrug solubility

Identifiers

PMID39065549
PMCPMC11279846

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.