Evidence map›Paper›PMID 39065211›Full record

ArticleMicroorganisms2024

Efficacy of a Multistrain Synbiotic Treatment in Acute and Post-Acute COVID-19 Patients: A Double-Blind, Placebo-Controlled Randomized Trial.

Maria Letizia Giancola, Andrea Fontana, Concetta Panebianco, Antonio Mazzarelli, Alessia Beccacece, Patrizia De Marco, Giovanna Cocomazzi, Chiara De Giuli, Germana Grassi, Carla Fontana and 6 more

Abstract read
In one paragraph

Article in Microorganisms, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Trial
  2. Review
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Maria Letizia GiancolaNational Institute for Infectious Diseases, INMI "Lazzaro Spallanzani", IRCCS, 00149 Rome, Italy.ORCID 0000-0003-2481-6621
Andrea FontanaBiostatistic Unit, Fondazione-IRCCS "Casa Sollievo della Sofferenza" Hospital, 71013 San Giovanni Rotondo, FG, Italy.ORCID 0000-0002-6660-5315
Concetta PanebiancoGastroenterology Unit, Fondazione-IRCCS "Casa Sollievo della Sofferenza" Hospital, Opera di San Pio da Pietrelcina, 71013 San Giovanni Rotondo, FG, Italy.
Antonio MazzarelliNational Institute for Infectious Diseases, INMI "Lazzaro Spallanzani", IRCCS, 00149 Rome, Italy.ORCID 0000-0001-6285-4368
Alessia BeccaceceNational Institute for Infectious Diseases, INMI "Lazzaro Spallanzani", IRCCS, 00149 Rome, Italy.
Patrizia De MarcoNational Institute for Infectious Diseases, INMI "Lazzaro Spallanzani", IRCCS, 00149 Rome, Italy.ORCID 0009-0002-7061-0472
Giovanna CocomazziGastroenterology Unit, Fondazione-IRCCS "Casa Sollievo della Sofferenza" Hospital, Opera di San Pio da Pietrelcina, 71013 San Giovanni Rotondo, FG, Italy.
Chiara De GiuliNational Institute for Infectious Diseases, INMI "Lazzaro Spallanzani", IRCCS, 00149 Rome, Italy.
Germana GrassiNational Institute for Infectious Diseases, INMI "Lazzaro Spallanzani", IRCCS, 00149 Rome, Italy.
Carla FontanaNational Institute for Infectious Diseases, INMI "Lazzaro Spallanzani", IRCCS, 00149 Rome, Italy.ORCID 0000-0003-2198-1947
Giorgio Maria BaldiniAO Consorziale Policlinico di Bari, Università Aldo Moro di Bari, 70121 Bari, BA, Italy.ORCID 0000-0002-5061-8007
Viviana ContuIntegrative Medicine Unit, Humanitas Gradenigo, Corso Regina Margherita 8/10, 10153 Torino, TO, Italy.ORCID 0009-0001-7774-365X
Massimiliano CopettiBiostatistic Unit, Fondazione-IRCCS "Casa Sollievo della Sofferenza" Hospital, 71013 San Giovanni Rotondo, FG, Italy.
Francesco PerriGastroenterology Unit, Fondazione-IRCCS "Casa Sollievo della Sofferenza" Hospital, Opera di San Pio da Pietrelcina, 71013 San Giovanni Rotondo, FG, Italy.ORCID 0000-0001-8314-8016
Emanuele NicastriNational Institute for Infectious Diseases, INMI "Lazzaro Spallanzani", IRCCS, 00149 Rome, Italy.ORCID 0000-0002-5606-8712
Valerio PazienzaGastroenterology Unit, Fondazione-IRCCS "Casa Sollievo della Sofferenza" Hospital, Opera di San Pio da Pietrelcina, 71013 San Giovanni Rotondo, FG, Italy.ORCID 0000-0002-3492-1153

Funding

Ricerca Corrente Program of the Italian Ministry of Health to the National Institute for Infectious Diseases Lazzaro Spallanzani IRCCS line 1 on emerging and re-emerging infections.
6 · The paper itself

Abstract

BACKGROUND AND

aimsSeveral studies reported the effect of COVID-19 on inducing gut dysbiosis, which is also correlated with disease severity. This study aims to investigate the effect of a nutraceutical formula on the shift of microbiota profiles and, secondly, on the clinical-pathological parameters of acute and post-acute COVID-19 patients.

methodsIn this randomised, double-blind, placebo-controlled trial conducted at National Institute for Infectious diseases (INMI) Lazzaro Spallanzani (Italy), 52 patients were randomly assigned (1:1) to receive a multistrain synbiotic formula (Kebirah

resultsSupplementation with Kebirah

conclusionsOur data suggest that modulating the gut microbiota in acute disease through administration of a specific symbiotic formula could be a useful strategy in the frame of SARS-CoV-2 infections.

Indexed as

microbiotaprobioticsSARS-CoV-2

Identifiers

PMID39065211
PMCPMC11279369

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.