Evidence map›Paper›PMID 39065154›Full record

ReviewMicroorganisms2024

The Relationship between Exposome and Microbiome.

Giuseppe Merra, Paola Gualtieri, Giada La Placa, Giulia Frank, David Della Morte, Antonino De Lorenzo, Laura Di Renzo

Abstract readReview
In one paragraph

Review in Microorganisms, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  6. Observational
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  9. Preparing the Bowel for Surgery in the Era of Microbiome Sciences.The Surgical clinics of North America · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Giuseppe MerraDepartment of Biomedicine and Prevention, Section of Clinical Nutrition and Nutrigenomics, University of Rome Tor Vergata, 00133 Rome, Italy.ORCID 0000-0003-4753-3528
Paola GualtieriDepartment of Biomedicine and Prevention, Section of Clinical Nutrition and Nutrigenomics, University of Rome Tor Vergata, 00133 Rome, Italy.ORCID 0000-0003-1533-4276
Giada La PlacaPh.D. School of Applied Medical-Surgical-Sciences, Univeristy of Rome Tor Vergata, 00133 Rome, Italy.
Giulia FrankPh.D. School of Applied Medical-Surgical-Sciences, Univeristy of Rome Tor Vergata, 00133 Rome, Italy.ORCID 0000-0003-4515-548X
David Della MorteDepartment of Biomedicine and Prevention, Section of Clinical Nutrition and Nutrigenomics, University of Rome Tor Vergata, 00133 Rome, Italy.ORCID 0000-0002-4054-5318
Antonino De LorenzoDepartment of Biomedicine and Prevention, Section of Clinical Nutrition and Nutrigenomics, University of Rome Tor Vergata, 00133 Rome, Italy.ORCID 0000-0001-6524-4493
Laura Di RenzoDepartment of Biomedicine and Prevention, Section of Clinical Nutrition and Nutrigenomics, University of Rome Tor Vergata, 00133 Rome, Italy.ORCID 0000-0001-8875-6723

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Currently, exposome studies include a raft of different monitoring tools, including remote sensors, smartphones, omics analyses, distributed lag models, etc. The similarity in structure between the exposome and the microbiota plus their functions led us to pose three pertinent questions from this viewpoint, looking at the actual relationship between the exposome and the microbiota. In terms of the exposome, a bistable equilibrium between health and disease depends on constantly dealing with an ever-changing totality of exposures that together shape an individual from conception to death. Regarding scientific knowledge, the exposome is still lagging in certain areas, like the importance of microorganisms in the equation. The human microbiome is defined as an aggregate assemblage of gut commensals that are hosted by our surfaces related to the external environment. Commensals' resistance to a variety of environmental exposures, such as antibiotic administration, confirms that a layer of these organisms is protected within the host. The exposome is a conceptual framework defined as the environmental component of the science-inspired systems ideology that shifts from a specificity-based medical approach to reasoning in terms of complexity. A parallel concept in population health research and precision public health is the human flourishing index, which aims to account for the numerous environmental factors that affect individual and population well-being beyond ambient pollution.

Indexed as

commensalsenvironmentalexposomemicrobiomeomicsorganisms

Identifiers

PMID39065154
PMCPMC11278511

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.