Evidence map›Paper›PMID 39065131›Full record

ArticleMicroorganisms2024

Mollaret's Meningitis due to Herpes Simplex Virus 2: A Case Report and Review of the Literature.

Liliana Gabrielli, Isabella Banchini, Evangelia Petrisli, Giulia Piccirilli, Simona Venturoli, Matteo Pavoni, Alessia Cantiani, Federica Lanna, Caterina Campoli, Matteo Montironi and 2 more

Abstract readCase Reports
In one paragraph

Article in Microorganisms, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Developments in genital herpes: progress in prevention and treatment.Current opinion in infectious diseases · 2026
    Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Liliana GabrielliMicrobiology Unit, IRCCS Azienda Ospedaliero-Universitaria di Bologna, 40138 Bologna, Italy.ORCID 0000-0002-5994-4749
Isabella BanchiniDepartment of Medical and Surgical Sciences, Section of Microbiology, University of Bologna, 40138 Bologna, Italy.
Evangelia PetrisliMicrobiology Unit, IRCCS Azienda Ospedaliero-Universitaria di Bologna, 40138 Bologna, Italy.ORCID 0000-0002-8214-9057
Giulia PiccirilliMicrobiology Unit, IRCCS Azienda Ospedaliero-Universitaria di Bologna, 40138 Bologna, Italy.ORCID 0000-0002-2596-2367
Simona VenturoliMicrobiology Unit, IRCCS Azienda Ospedaliero-Universitaria di Bologna, 40138 Bologna, Italy.
Matteo PavoniDepartment of Medical and Surgical Sciences, Section of Microbiology, University of Bologna, 40138 Bologna, Italy.
Alessia CantianiDepartment of Medical and Surgical Sciences, Section of Microbiology, University of Bologna, 40138 Bologna, Italy.
Federica LannaDepartment of Medical and Surgical Sciences, Section of Microbiology, University of Bologna, 40138 Bologna, Italy.
Caterina CampoliInfectious Diseases Unit, IRCCS Azienda Ospedaliero-Universitaria di Bologna, 40138 Bologna, Italy.ORCID 0000-0002-5951-639X
Matteo MontironiInfectious Diseases Unit, IRCCS Azienda Ospedaliero-Universitaria di Bologna, 40138 Bologna, Italy.
Maddalena GiannellaInfectious Diseases Unit, IRCCS Azienda Ospedaliero-Universitaria di Bologna, 40138 Bologna, Italy.
Tiziana LazzarottoMicrobiology Unit, IRCCS Azienda Ospedaliero-Universitaria di Bologna, 40138 Bologna, Italy.ORCID 0000-0003-3093-363X

Funding

NextGenerationEU-MUR PNRR PE00000007
6 · The paper itself

Abstract

Mollaret's meningitis is a rare neurological disorder characterized by recurrent episodes of aseptic lymphocytic meningitis, often associated with herpes simplex virus 2 (HSV-2) infection. We report the case of a 39 y.o. Italian woman who experienced four episodes of aseptic lymphocytic meningitis between 2004 and 2023, diagnosed as Mollaret's meningitis. In each episode, the patient presented with fever, severe headache and photophobia. In two episodes cutaneous vesicles in the left gluteal area preceding meningitis symptoms were also reported. A diagnostic evaluation included a physical-chemical analysis and a real-time PCR of the cerebrospinal fluid (CSF). The CSF presented pleocytosis with lymphocytic predominance and a positive HSV-2 load, with a peak of 1234 copies/mL. The patient was treated successfully with acyclovir, and the symptoms resolved without neurological sequelae. This case highlights the importance of comprehensive diagnostic testing and vigilant monitoring to manage Mollaret's syndrome effectively.

Indexed as

acycloviraseptic meningitisherpes simplex virus 2Mollaret’s meningitis

Identifiers

PMID39065131
PMCPMC11278522

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.