Evidence map›Paper›PMID 39065125›Full record

ArticleMicroorganisms2024

Oral Microbiota Alterations in Subjects with SARS-CoV-2 Displaying Prevalence of the Opportunistic Fungal Pathogen

Areej A Alfaifi, Johanna B Holm, Tristan W Wang, Jonathan Lim, Timothy F Meiller, Peter Rock, Ahmed S Sultan, Mary Ann Jabra-Rizk

Abstract read
In one paragraph

Article in Microorganisms, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Areej A AlfaifiDepartment of Oncology and Diagnostic Sciences, School of Dentistry, University of Maryland Baltimore, Baltimore, MD 21201, USA.
Johanna B HolmInstitute for Genome Sciences, School of Medicine, University of Maryland, Baltimore, MD 21201, USA.
Tristan W WangDepartment of Oncology and Diagnostic Sciences, School of Dentistry, University of Maryland Baltimore, Baltimore, MD 21201, USA.ORCID 0000-0001-6889-2453
Jonathan LimInstitute for Genome Sciences, School of Medicine, University of Maryland, Baltimore, MD 21201, USA.
Timothy F MeillerDepartment of Oncology and Diagnostic Sciences, School of Dentistry, University of Maryland Baltimore, Baltimore, MD 21201, USA.
Peter RockDepartment of Anesthesia, School of Medicine, University of Maryland, Baltimore, MD 21201, USA.ORCID 0000-0003-2250-5926
Ahmed S SultanDepartment of Oncology and Diagnostic Sciences, School of Dentistry, University of Maryland Baltimore, Baltimore, MD 21201, USA.ORCID 0000-0001-5286-4562
Mary Ann Jabra-RizkDepartment of Oncology and Diagnostic Sciences, School of Dentistry, University of Maryland Baltimore, Baltimore, MD 21201, USA.ORCID 0000-0002-4425-3873

Funding

Impact of SARS-CoV-2 mediated salivary gland dysfunction on secreted salivary antimicrobial peptides and the risk for oral opportunistic infectionsR21DE031888 · NIDCR · UNIVERSITY OF MARYLAND BALTIMORE · PI JABRA-RIZK, MARY ANN Y · 2022 to 2023
$425k
Quorum Sensing Cholera ScreeningZIATR000309 · NCATS · NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES · PI SIMEONOV, ANTON · 2017 to 2017
$45k
National Institute for Health (NIDCR) R21DE031888University of Maryland Baltimore, Institute for Clinical & Translational Research (ICTR) 1UL1TR00309
6 · The paper itself

Abstract

The oral cavity remains an underappreciated site for SARS-CoV-2 infection despite the myriad of oral conditions in COVID-19 patients. Recently, SARS-CoV-2 was shown to replicate in the salivary gland cells causing tissue inflammation. Given the established association between inflammation and microbiome disruption, we comparatively profiled oral microbial differences at a metagenomic level in a cohort of hospitalized COVID-19 patients and matched healthy controls. Specifically, we aimed to evaluate colonization by the opportunistic fungal pathogen

Indexed as

Candida albicansCOVID-19microbiomeoralSARS-CoV-2

Identifiers

PMID39065125
PMCPMC11278750

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.