Evidence map›Paper›PMID 39064944›Full record

ArticleMolecules (Basel, Switzerland)2024

Efficient Synthesis, Structural Characterization, Antibacterial Assessment, ADME-Tox Analysis, Molecular Docking and Molecular Dynamics Simulations of New Functionalized Isoxazoles.

Aziz Arzine, Hanine Hadni, Khalid Boujdi, Khalid Chebbac, Najoua Barghady, Yassine Rhazi, Mohammed Chalkha, Asmae Nakkabi, Karim Chkirate, Joel T Mague and 4 more

Abstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

  1. Advancing infection therapy: the role of novel menthol-based antimicrobials.Journal of enzyme inhibition and medicinal chemistry · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Aziz ArzineEngineering Laboratory of Organometallic, Molecular Materials and Environment, Faculty of Sciences Dhar EL Mahraz, Sidi Mohamed Ben Abdellah University, P.O. Box 1796, Atlas, Fez 30000, Morocco.
Hanine HadniLIMAS, Faculty of Sciences Dhar El Mahraz, Sidi Mohamed Ben Abdellah University, P.O. Box 1796, Atlas, Fez 30000, Morocco.ORCID 0000-0002-4952-9533
Khalid BoujdiFaculty of Sciences and Technologies Mohammedia, University Hassan II, B.P. 146, Mohammedia 28800, Morocco.ORCID 0009-0009-5112-0049
Khalid ChebbacLaboratory of Biotechnology Conservation and Valorisation of Natural Resources, Faculty of Sciences Dhar El Mahraz, Sidi Mohamed Ben Abdallah University, Fez 30000, Morocco.ORCID 0000-0002-8511-6859
Najoua BarghadyEngineering Laboratory of Organometallic, Molecular Materials and Environment, Faculty of Sciences Dhar EL Mahraz, Sidi Mohamed Ben Abdellah University, P.O. Box 1796, Atlas, Fez 30000, Morocco.
Yassine RhaziEngineering Laboratory of Organometallic, Molecular Materials and Environment, Faculty of Sciences Dhar EL Mahraz, Sidi Mohamed Ben Abdellah University, P.O. Box 1796, Atlas, Fez 30000, Morocco.
Mohammed ChalkhaEngineering Laboratory of Organometallic, Molecular Materials and Environment, Faculty of Sciences Dhar EL Mahraz, Sidi Mohamed Ben Abdellah University, P.O. Box 1796, Atlas, Fez 30000, Morocco.ORCID 0000-0002-9400-2183
Asmae NakkabiEngineering Laboratory of Organometallic, Molecular Materials and Environment, Faculty of Sciences Dhar EL Mahraz, Sidi Mohamed Ben Abdellah University, P.O. Box 1796, Atlas, Fez 30000, Morocco.
Karim ChkirateLaboratory of Heterocyclic Organic Chemistry URAC 21, Pharmacochemistry Competence Center, Av. Ibn Battouta, BP 1014, Faculty of Sciences, Mohammed V University in Rabat, Rabat 10010, Morocco.ORCID 0000-0002-9996-4963
Joel T MagueDepartment of Chemistry, Tulane University, New Orleans, LA 70118, USA.ORCID 0000-0003-3488-1945
Sarkar M A KawsarLaboratory of Carbohydrate and Nucleoside Chemistry (LCNC), Department of Chemistry, Faculty of Science, University of Chittagong, Chittagong 4331, Bangladesh.ORCID 0000-0001-7964-9117
Ghali Al HouariEngineering Laboratory of Organometallic, Molecular Materials and Environment, Faculty of Sciences Dhar EL Mahraz, Sidi Mohamed Ben Abdellah University, P.O. Box 1796, Atlas, Fez 30000, Morocco.ORCID 0000-0003-1180-9633
Mohammed M AlanaziDepartment of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, Riyadh 11451, Saudi Arabia.ORCID 0000-0002-0483-8113
Mohamed El YazidiEngineering Laboratory of Organometallic, Molecular Materials and Environment, Faculty of Sciences Dhar EL Mahraz, Sidi Mohamed Ben Abdellah University, P.O. Box 1796, Atlas, Fez 30000, Morocco.ORCID 0000-0002-2772-6632

Funding

the Researchers Supporting Project number (RSPD2024R628), King Saud University, Riyadh, Saudi Arabia RSPD2024R628
6 · The paper itself

Abstract

This work describes the synthesis, characterization, and in vitro and in silico evaluation of the biological activity of new functionalized isoxazole derivatives. The structures of all new compounds were analyzed by IR and NMR spectroscopy. The structures of

Indexed as

Anti-Bacterial AgentsIsoxazolesMolecular Docking SimulationMolecular Dynamics SimulationBacillus subtilisEscherichia coliMicrobial Sensitivity TestsMolecular StructureStaphylococcus aureusStructure-Activity RelationshipAnti-Bacterial AgentsIsoxazolesADME-Toxantibacterial activitycrystal structuredockingisoxazole-ester conjugatesMD simulation

Identifiers

PMID39064944
PMCPMC11279828

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.