Evidence map›Paper›PMID 39064821›Full record

ArticleNutrients2024

Effectiveness of Combination of Tibolone and

Vincenzo De Leo, Laura Governini, Rosetta Ponchia, Dario Recalcati, Filippo Murina

Abstract read
In one paragraph

Article in Nutrients, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Vincenzo De LeoMedical Office "Colledoro", 53100 Siena, Italy.
Laura GoverniniDepartment of Molecular and Developmental Medicine, University of Siena, 53100 Siena, Italy.ORCID 0000-0001-5610-9548
Rosetta PonchiaDepartment of Molecular and Developmental Medicine, University of Siena, 53100 Siena, Italy.
Dario RecalcatiLower Genital Tract Disease Unit, V. Buzzi Hospital, University of the Study of Milan, 20124 Milan, Italy.
Filippo MurinaLower Genital Tract Disease Unit, V. Buzzi Hospital, University of the Study of Milan, 20124 Milan, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPostmenopausal dyspareunia and vulvar pain are common complaints, affecting about 60% of women within a few years after hormone levels begin to decline (such as estrogen and androgen). Atrophic changes mainly located in the vulvar vestibule and vulnerability to vulvovaginal infections in postmenopause could be predisposing factors to the development of vulvar burning/pain and introital dyspareunia (vestibulodynia secondary to atrophy). Tibolone is the most effective and safe alternative for treating menopausal symptoms. The role of

methodsIn this study, we included 35 postmenopausal women with at least 1 year of amenorrhea, affected by vulvar burning/pain and introital dyspareunia. All participants received treatment with open-label, oral Tibolone 2.5 mg and

resultsAfter 90 d of therapy with TIB+ Respecta

conclusionsThis study provides evidence that the combination of TIB+ Respecta

Indexed as

LactobacillusLactoferrinNorpregnenesPostmenopauseDyspareuniaFemaleHumansMiddle AgedProbioticsTreatment OutcomeVulvaVulvodyniaLactoferrinNorpregnenestiboloneLactobacillilactoferrintibolonevestibulodyniavulvar pain

Identifiers

PMID39064821
PMCPMC11280312

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.