Evidence map›Paper›PMID 39064768›Full record

Trial reportNutrients2024

Functional Foods and Adapted Physical Activity as New Adjuvant Therapy for Chronic Kidney Disease Patients.

Giulia Marrone, Arianna Murri, Silvia Urciuoli, Manuela Di Lauro, Elisa Grazioli, Pamela Vignolini, Kevin Cornali, Eliana Tranchita, Claudia Masci, Claudia Cerulli and 4 more

Abstract readRandomized Controlled Trial
In one paragraph

Trial report in Nutrients, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Trial
  3. Trial
  4. Article
  5. Review
  6. Review
  7. Lifestyle and Environment Aspects Challenging Kidney Health.Kidney & blood pressure research · 2026
    Review
  8. Article
  9. Article
  10. Review
  11. Review
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Giulia MarroneDepartment of Systems Medicine, University of Rome Tor Vergata, 00133 Rome, Italy.ORCID 0000-0002-5854-2086
Arianna MurriDepartment of Exercise, Human and Health Sciences, Foro Italico University of Rome, 00135 Rome, Italy.ORCID 0000-0003-4642-6317
Silvia UrciuoliDepartment of Statistics, Computer Science and Application-PHYTOLAB (Pharmaceutical, Cosmetic, Food Supplement, Technology and Analysis), University of Florence, Sesto Fiorentino, 50019 Florence, Italy.ORCID 0000-0001-8139-3229
Manuela Di LauroDepartment of Systems Medicine, University of Rome Tor Vergata, 00133 Rome, Italy.ORCID 0000-0001-8118-1330
Elisa GrazioliDepartment of Exercise, Human and Health Sciences, Foro Italico University of Rome, 00135 Rome, Italy.ORCID 0000-0003-4245-1320
Pamela VignoliniDepartment of Statistics, Computer Science and Application-PHYTOLAB (Pharmaceutical, Cosmetic, Food Supplement, Technology and Analysis), University of Florence, Sesto Fiorentino, 50019 Florence, Italy.ORCID 0000-0002-9500-7971
Kevin CornaliDepartment of Systems Medicine, University of Rome Tor Vergata, 00133 Rome, Italy.ORCID 0009-0004-8904-4399
Eliana TranchitaDepartment of Exercise, Human and Health Sciences, Foro Italico University of Rome, 00135 Rome, Italy.
Claudia MasciDepartment of Systems Medicine, University of Rome Tor Vergata, 00133 Rome, Italy.
Claudia CerulliDepartment of Exercise, Human and Health Sciences, Foro Italico University of Rome, 00135 Rome, Italy.ORCID 0000-0003-2637-7968
Luca Di MarcoDepartment of Systems Medicine, University of Rome Tor Vergata, 00133 Rome, Italy.ORCID 0009-0006-8173-8761
Anna Paola MitterhoferDepartment of Systems Medicine, University of Rome Tor Vergata, 00133 Rome, Italy.ORCID 0000-0002-0132-386X
Attilio ParisiDepartment of Exercise, Human and Health Sciences, Foro Italico University of Rome, 00135 Rome, Italy.ORCID 0000-0003-2648-8406
Annalisa NoceDepartment of Systems Medicine, University of Rome Tor Vergata, 00133 Rome, Italy.ORCID 0000-0003-1310-3730

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundChronic kidney disease (CKD) will become the fifth leading cause of death in the world by 2040. It is fundamental to prevent and treat this pathology to reduce its impact on national health costs. This trial's aim is to evaluate the effects induced by a combination of consumed functional foods (FFs) with adapted physical activity (APA) on the progression of CKD-related comorbidities.

methodsThe study lasted 12 weeks. We divided 40 CKD patients into four groups: mixed (FF + APA), APA, FF and control group (usual care). The FFs were characterized by their total antioxidant capacity and antiradical activity. The APA was performed though an online training protocol, three times per week, 1 h each session.

resultsAt the end of the study, we observed, in the mixed group, a decrease in azotemia (

conclusionsThe combination of FFs and APA can help counteract several CKD-related comorbidities, such as arterial hypertension, dyslipidemia and uremic sarcopenia, and improve the CKD patients' quality of life.

Indexed as

ExerciseFunctional FoodRenal Insufficiency, ChronicAgedAntioxidantsComorbidityExercise TherapyFemaleHumansMaleMiddle AgedAntioxidantscircular economyextra virgin olive oilfunctional foodsnatural bioactive compoundsnon-communicable diseasessarcopenia

Identifiers

PMID39064768
PMCPMC11279472

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.