Evidence map›Paper›PMID 39064756›Full record

ArticleNutrients2024

Enhancing Vascular Health and Lowering Blood Pressure in Spontaneously Hypertensive Rats through Syrah Grape (

Kelly C M da Costa, Lorrayne de S Oliveira, Júlia C Silva, Taynara S Santana, Raiany A de Freitas, Alecsander F M Bressan, Sérgio Gómez-Alonso, José Pérez-Navarro, Paula B Pertuzatti, Fernanda R Giachini

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nutrients, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Kelly C M da CostaInstitute of Biological and Health Sciences, Federal University of Mato Grosso, Barra do Garças 78060-900, Brazil.
Lorrayne de S OliveiraInstitute of Biological and Health Sciences, Federal University of Mato Grosso, Barra do Garças 78060-900, Brazil.
Júlia C SilvaInstitute of Exact and Earth Sciences, Federal University of Mato Grosso, Barra do Garças 78060-900, Brazil.
Taynara S SantanaInstitute of Biological and Health Sciences, Federal University of Mato Grosso, Barra do Garças 78060-900, Brazil.ORCID 0009-0007-6421-9684
Raiany A de FreitasInstitute of Biological and Health Sciences, Federal University of Mato Grosso, Barra do Garças 78060-900, Brazil.
Alecsander F M BressanInstitute of Biological and Health Sciences, Federal University of Mato Grosso, Barra do Garças 78060-900, Brazil.ORCID 0000-0001-7629-8972
Sérgio Gómez-AlonsoRegional Institute of Applied Scientific Research, University of Castilla-La Mancha, 13071 Ciudad Real, Spain.ORCID 0000-0002-2358-6636
José Pérez-NavarroRegional Institute of Applied Scientific Research, University of Castilla-La Mancha, 13071 Ciudad Real, Spain.ORCID 0000-0003-1614-0633
Paula B PertuzattiInstitute of Exact and Earth Sciences, Federal University of Mato Grosso, Barra do Garças 78060-900, Brazil.ORCID 0000-0001-8130-9680
Fernanda R GiachiniInstitute of Biological and Health Sciences, Federal University of Mato Grosso, Barra do Garças 78060-900, Brazil.ORCID 0000-0003-2688-7204

Funding

Coordenação de Aperfeicoamento de Pessoal de Nível Superior Financing Code 001Fundação de Amparo à Pesquisa do Estado de Mato Grosso 0000443/2022National Council for Scientific and Technological Development 407374/2021-3
6 · The paper itself

Abstract

backgroundThe beneficial properties of wine by-products include actions that help prevent and treat cardiovascular conditions such as hypertension, primarily due to their antioxidant effects. Novel pharmacotherapies are being developed to treat arterial hypertension, including investigations into natural products exhibiting biological activity, necessitating rigorous evaluation of their efficacy and safety. This study aimed to identify and quantify phenolic compounds in Syrah (

methodsFresh grapes, pomace, and lees, were subjected to spectrophotometric determination of total phenolic compounds, followed by identification and quantification using HPLC-DAD-ESI-MSn. Normotensive male rats (Wistar) and spontaneously hypertensive rats (SHR) received grape pomace-enriched (150 or 300 mg/kg/day, 14 days) or standard chow. Indirect arterial pressure was assessed, while vascular reactivity was evaluated in mesenteric resistance arteries.

resultsPomace samples exhibited higher total phenolic compound concentrations than grapes or lees. Seven derivatives of hydroxycinnamic acids and twenty-one flavonols were identified. Quercetin-3-glucoside and ethyl caffeate were the most abundant phenolic compounds. Grape pomace-enriched chow demonstrated a dose-dependent hypotensive effect in rats.

conclusionthe abundance of flavonols and hydroxycinnamic acids, combined with their hypotensive effects, underscores the therapeutic potential of fine wine-making by-products produced in the Brazilian Cerrado.

Indexed as

Antihypertensive AgentsBlood PressureHypertensionPhenolsRats, Inbred SHRRats, WistarVitisWineAnimalsAntioxidantsBrazilFruitMalePlant ExtractsRatsAntihypertensive AgentsAntioxidantsPhenolsPlant Extractsflavonolsgrape pomacehydroxycinnamic acidshypertensionleeswinery waste

Identifiers

PMID39064756
PMCPMC11279649

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.