Evidence map›Paper›PMID 39064706›Full record

ArticleNutrients2024

Effect of Urolithin A on the Improvement of Circadian Rhythm Dysregulation in Intestinal Barrier Induced by Inflammation.

Yao Du, Xinyue Chen, Susumu Kajiwara, Kanami Orihara

Abstract read
In one paragraph

Article in Nutrients, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
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  5. Article
  6. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Yao DuSchool of Life Science and Technology, Tokyo Institute of Technology, Yokohama 226-8501, Japan.
Xinyue ChenSchool of Life Science and Technology, Tokyo Institute of Technology, Yokohama 226-8501, Japan.ORCID 0000-0001-9276-8209
Susumu KajiwaraSchool of Life Science and Technology, Tokyo Institute of Technology, Yokohama 226-8501, Japan.
Kanami OriharaSchool of Life Science and Technology, Tokyo Institute of Technology, Yokohama 226-8501, Japan.ORCID 0000-0002-2652-4529

Funding

Kobayashi Foundation The 10th (2021FY) Grant
6 · The paper itself

Abstract

Circadian rhythm plays an important role in intestinal homeostasis and intestinal immune function. Circadian rhythm dysregulation was reported to induce intestinal microbiota dysbiosis, intestinal barrier disruption, and trigger intestinal inflammation. However, the relationship between intestinal microbiota metabolites and the circadian rhythm of the intestinal barrier was still unclear. Urolithin A (UA), a kind of intestinal microbial metabolite, was selected in this study. Results showed UA influenced on the expression rhythm of the clock genes

Indexed as

Circadian RhythmColitisCoumarinsIntestinal MucosaMice, Inbred C57BLAnimalsARNTL Transcription FactorsDextran SulfateDisease Models, AnimalFemaleGastrointestinal MicrobiomeGene Expression RegulationHumansImmunoglobulin AInflammationMice3,8-dihydroxy-6H-dibenzo(b,d)pyran-6-oneARNTL Transcription FactorsBmal1 protein, mouseCoumarinsDextran SulfateImmunoglobulin ANfe2l2 protein, mouseNF-E2-Related Factor 2Per2 protein, mousePeriod Circadian ProteinsSirt1 protein, mouseSirtuin 1circadian rhythmclock geneIBDIgAintestinal barriertight junctionUrolithin A

Identifiers

PMID39064706
PMCPMC11280374

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.