Evidence map›Paper›PMID 39064624›Full record

ArticleNutrients2024

Insulin-Mimetic Activity of Herbal Extracts Identified with Large-Scale Total Internal Reflection Fluorescence Microscopy.

Cathrina Neuhauser, Bettina Schwarzinger, Clemens Schwarzinger, Michaela Feichtinger, Verena Stadlbauer, Verena Arnaut, Ivana Drotarova, Bernhard Blank-Landeshammer, Julian Weghuber

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nutrients, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Study of the Hypoglycemic Activity of Rhamnolipids Using theCurrent issues in molecular biology · 2026
    Article
  2. Article
  3. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Cathrina NeuhauserCenter of Excellence Food Technology and Nutrition, University of Applied Sciences Upper Austria, Stelzhamerstraße 23, 4600 Wels, Austria.
Bettina SchwarzingerCenter of Excellence Food Technology and Nutrition, University of Applied Sciences Upper Austria, Stelzhamerstraße 23, 4600 Wels, Austria.
Clemens SchwarzingerInstitute for Chemical Technology of Organic Materials, Johannes Kepler University, 4040 Linz, Austria.ORCID 0000-0002-8421-9063
Michaela FeichtingerCenter of Excellence Food Technology and Nutrition, University of Applied Sciences Upper Austria, Stelzhamerstraße 23, 4600 Wels, Austria.
Verena StadlbauerCenter of Excellence Food Technology and Nutrition, University of Applied Sciences Upper Austria, Stelzhamerstraße 23, 4600 Wels, Austria.ORCID 0009-0003-4875-3239
Verena ArnautCenter of Excellence Food Technology and Nutrition, University of Applied Sciences Upper Austria, Stelzhamerstraße 23, 4600 Wels, Austria.
Ivana DrotarovaCenter of Excellence Food Technology and Nutrition, University of Applied Sciences Upper Austria, Stelzhamerstraße 23, 4600 Wels, Austria.ORCID 0009-0005-9342-5204
Bernhard Blank-LandeshammerFFoQSI GmbH-Austrian Competence Centre for Feed and Food Quality, Safety and Innovation, Technopark 1D, 3430 Tulln, Austria.ORCID 0000-0003-1996-1162
Julian WeghuberCenter of Excellence Food Technology and Nutrition, University of Applied Sciences Upper Austria, Stelzhamerstraße 23, 4600 Wels, Austria.ORCID 0000-0001-6312-4666

Funding

Austrian research promotion agency 881882Christian Doppler Forschungsgesellschaft Josef Ressel Center for Phytogenic Drug Research
6 · The paper itself

Abstract

Diabetes mellitus is a spreading global pandemic. Type 2 diabetes mellitus (T2DM) is the predominant form of diabetes, in which a reduction in blood glucose uptake is caused by impaired glucose transporter 4 (GLUT4) translocation to the plasma membrane in adipose and muscle cells. Antihyperglycemic drugs play a pivotal role in ameliorating diabetes symptoms but often are associated with side effects. Hence, novel antidiabetic compounds and nutraceutical candidates are urgently needed. Phytogenic therapy can support the prevention and amelioration of impaired glucose homeostasis. Using total internal reflection fluorescence microscopy (TIRFM), 772 plant extracts of an open-access plant extract library were screened for their GLUT4 translocation activation potential, resulting in 9% positive hits. Based on commercial interest and TIRFM assay-based GLUT4 translocation activation, some of these extracts were selected, and their blood glucose-reducing effects in ovo were investigated using a modified hen's egg test (Gluc-HET). To identify the active plant part, some of the available candidate plants were prepared in-house from blossoms, leaves, stems, or roots and tested.

Indexed as

Glucose Transporter Type 4Hypoglycemic AgentsInsulinMicroscopy, FluorescencePlant ExtractsAnimalsBlood GlucoseDiabetes Mellitus, Type 2HumansMiceProtein TransportBlood GlucoseGlucose Transporter Type 4Hypoglycemic AgentsInsulinPlant ExtractsAcacia catechudiabetes mellitusGLUT4 translocationinsulin-mimetic compoundsMentha spicatamodified hens egg test (Gluc-HET)Pulmonaria officinalisSaponaria officinalistotal internal reflection fluorescence microscopy (TIRFM)

Identifiers

PMID39064624
PMCPMC11280383

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.