Evidence map›Paper›PMID 39063989›Full record

ArticleJournal of personalized medicine2024

Dupilumab Improves Facial Pain and Reduces Rescue Treatments in Patients with CRSwNP and Recalcitrant Frontal Sinusitis.

Eugenio De Corso, Stefano Settimi, Daniele Penazzi, Giuseppe D'Agostino, Marco Corbò, Mario Rigante, Claudio Montuori, Alberta Rizzuti, Maria Clara Pacilli, Tiziana Di Cesare and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of personalized medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Eugenio De CorsoUnit of Otorhinolaryngology and Head-Neck Surgery, "A. Gemelli" University Hospital Foundation IRCCS, 00168 Rome, Italy.ORCID 0000-0001-5761-7018
Stefano SettimiUnit of Otorhinolaryngology and Head-Neck Surgery, "A. Gemelli" University Hospital Foundation IRCCS, 00168 Rome, Italy.ORCID 0000-0003-0104-1501
Daniele PenazziDepartment of Head-Neck and Sensory Organs, Catholic University of Sacred Heart, 00168 Rome, Italy.
Giuseppe D'AgostinoDepartment of Head-Neck and Sensory Organs, Catholic University of Sacred Heart, 00168 Rome, Italy.
Marco CorbòDepartment of Head-Neck and Sensory Organs, Catholic University of Sacred Heart, 00168 Rome, Italy.
Mario RiganteUnit of Otorhinolaryngology and Head-Neck Surgery, "A. Gemelli" University Hospital Foundation IRCCS, 00168 Rome, Italy.ORCID 0000-0002-6111-0786
Claudio MontuoriDepartment of Head-Neck and Sensory Organs, Catholic University of Sacred Heart, 00168 Rome, Italy.ORCID 0000-0003-2070-0314
Alberta RizzutiDepartment of Head-Neck and Sensory Organs, Catholic University of Sacred Heart, 00168 Rome, Italy.ORCID 0009-0005-9826-0517
Maria Clara PacilliDepartment of Head-Neck and Sensory Organs, Catholic University of Sacred Heart, 00168 Rome, Italy.
Tiziana Di CesareUnit of Otorhinolaryngology and Head-Neck Surgery, "A. Gemelli" University Hospital Foundation IRCCS, 00168 Rome, Italy.
Simone Lo VerdeDepartment of Head-Neck and Sensory Organs, Catholic University of Sacred Heart, 00168 Rome, Italy.
Angela RizziUnit of Allergology e Clinical Immunology, "A. Gemelli" Hospital Foundation IRCCS, 00168 Rome, Italy.ORCID 0000-0002-6795-746X
Raffaella ChiniUnit of Allergology e Clinical Immunology, "A. Gemelli" Hospital Foundation IRCCS, 00168 Rome, Italy.
Jacopo GalliUnit of Otorhinolaryngology and Head-Neck Surgery, "A. Gemelli" University Hospital Foundation IRCCS, 00168 Rome, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Recalcitrant frontal sinusitis in patients with chronic rhinosinusitis and nasal polyps (CRSwNP) has a negative impact on their quality of life due to frontal pain and a high risk of sinus occlusion, thus necessitating antibiotics, systemic corticosteroids, and multiple surgeries. The aim of this study was to assess the efficacy of dupilumab in reducing frontal pain and the need for rescue treatments for recalcitrant frontal sinusitis in patients with CRSwNP. We enrolled a cohort of 10 patients with severe uncontrolled CRSwNP and concomitant recurrent frontal sinusitis associated with severe facial pain measured by MIDAS score who were treated with dupilumab 300 mg every 2 weeks and followed for at least 12 months. The mean MIDAS score decreased from 45.6 ± 10.7 at baseline to 1.3 ± 2.3 at 6 months (

Indexed as

biologicschronic rhinosinusitisendoscopic sinus surgeryfrontal sinusitisheadachenasal polypsoral corticosteroids

Identifiers

PMID39063989
PMCPMC11277593

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.