Evidence map›Paper›PMID 39063610›Full record

ReviewLife (Basel, Switzerland)2024

The Interplay between Obesity and Inflammation.

Ilinca Savulescu-Fiedler, Razvan Mihalcea, Serban Dragosloveanu, Cristian Scheau, Radu Octavian Baz, Ana Caruntu, Andreea-Elena Scheau, Constantin Caruntu, Serban Nicolae Benea

Abstract readReview
In one paragraph

Review in Life (Basel, Switzerland), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 78 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
78citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

78 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. ProbioticNarra J · 2025
    Pooled it
  3. Article
  4. Article
  5. Review
  6. Review
  7. Palmitoylethanolamide in Human and Animal Obesity.Molecules (Basel, Switzerland) · 2026
    Review
  8. Review
  9. Article
  10. Review
  11. Review
  12. Article
  13. Review
  14. The effect of oral protein and carbohydrate solution administration on NLR, IL-6 and CRP levels in patients undergoing surgery.Journal of critical care medicine (Universitatea de Medicina si Farmacie din Targu-Mures) · 2026
    Article
  15. Review
  16. Article
  17. Review
  18. Review
  19. Observational
  20. Article

18 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Ilinca Savulescu-FiedlerDepartment of Internal Medicine, The "Carol Davila" University of Medicine and Pharmacy, 050474 Bucharest, Romania.
Razvan MihalceaDepartment of Internal Medicine and Cardiology, Coltea Clinical Hospital, 030167 Bucharest, Romania.
Serban DragosloveanuDepartment of Orthopaedics, "Foisor" Clinical Hospital of Orthopaedics, Traumatology and Osteoarticular TB, 021382 Bucharest, Romania.ORCID 0000-0001-7403-1684
Cristian ScheauDepartment of Physiology, The "Carol Davila" University of Medicine and Pharmacy, 050474 Bucharest, Romania.ORCID 0000-0001-7676-6393
Radu Octavian BazClinical Laboratory of Radiology and Medical Imaging, "Sf. Apostol Andrei" County Emergency Hospital, 900591 Constanta, Romania.
Ana CaruntuDepartment of Oral and Maxillofacial Surgery, "Carol Davila" Central Military Emergency Hospital, 010825 Bucharest, Romania.ORCID 0000-0003-4200-3069
Andreea-Elena ScheauDepartment of Radiology and Medical Imaging, Fundeni Clinical Institute, 022328 Bucharest, Romania.ORCID 0000-0002-3360-2628
Constantin CaruntuDepartment of Physiology, The "Carol Davila" University of Medicine and Pharmacy, 050474 Bucharest, Romania.ORCID 0000-0003-4530-7965
Serban Nicolae BeneaDepartment of Infectious Diseases, The "Carol Davila" University of Medicine and Pharmacy, 050474 Bucharest, Romania.

Funding

Ministry of Research, Innovation and Digitization PN-III-P2-2.1-PED-2021-2243
6 · The paper itself

Abstract

Obesity is an important condition affecting the quality of life of numerous patients and increasing their associated risk for multiple diseases, including tumors and immune-mediated disorders. Inflammation appears to play a major role in the development of obesity and represents a central point for the activity of cellular and humoral components in the adipose tissue. Macrophages play a key role as the main cellular component of the adipose tissue regulating the chronic inflammation and modulating the secretion and differentiation of various pro- and anti-inflammatory cytokines. Inflammation also involves a series of signaling pathways that might represent the focus for new therapies and interventions. Weight loss is essential in decreasing cardiometabolic risks and the degree of associated inflammation; however, the latter can persist for long after the excess weight is lost, and can involve changes in macrophage phenotypes that can ensure the metabolic adjustment. A clear understanding of the pathophysiological processes in the adipose tissue and the interplay between obesity and chronic inflammation can lead to a better understanding of the development of comorbidities and may ensure future targets for the treatment of obesity.

Indexed as

adipocytesadipokinesadipose tissuecytokinesinflammationmacrophagesobesityweight loss

Identifiers

PMID39063610
PMCPMC11277997

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.