Self-Generated Lower Body Negative Pressure Exercise: A Low Power Countermeasure for Acute Space Missions.

Suhas Rao Velichala, Ryan D Kassel, Victoria Ly, Donald E Watenpaugh, Stuart M C Lee, Brandon R Macias, Alan R Hargens

Abstract read

In one paragraph

Article in Life (Basel, Switzerland), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

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0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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5 · Who and what money

Authors and funding

7 authors.

Suhas Rao VelichalaDepartment of Orthopaedic Surgery, UC San Diego Medical Center, University of California San Diego, La Jolla, CA 92093, USA.ORCID 0000-0002-3270-338X

Ryan D KasselDepartment of Orthopaedic Surgery, UC San Diego Medical Center, University of California San Diego, La Jolla, CA 92093, USA.

Victoria LyDepartment of Orthopaedic Surgery, UC San Diego Medical Center, University of California San Diego, La Jolla, CA 92093, USA.ORCID 0009-0005-3988-4266

Donald E WatenpaughDepartment of Physiology and Anatomy, University of North Texas Health Science Center, Fort Worth, TX 76107, USA.

Stuart M C LeeNational Aeronautics and Space Administration, Huntsville, AL 35808, USA.ORCID 0000-0001-7065-5182

Brandon R MaciasNational Aeronautics and Space Administration, Huntsville, AL 35808, USA.

Alan R HargensDepartment of Orthopaedic Surgery, UC San Diego Medical Center, University of California San Diego, La Jolla, CA 92093, USA.

Funding

National Aeronautics and Space Administration (NASA) NASA 80NSSC19K0409

6 · The paper itself

Abstract

Microgravity in spaceflight produces headward fluid shifts which probably contribute to Spaceflight-Associated Neuro-Ocular Syndrome (SANS). Developing new methods to mitigate these shifts is crucial for preventing SANS. One possible strategy is the use of self-generated lower body negative pressure (LBNP). This study evaluates biological or physiological effects induced by bed rest to simulate adaptations to microgravity. Participants were tested during powered LBNP and dynamic self-generated (SELF) LBNP at 25 mmHg for 15 min. The results were compared to the physiologic responses observed in seated upright and supine positions without LBNP, which served as controls for normal gravitational effects on fluid dynamics. Eleven participants' (five male, six female) heart rates, blood pressures, and cross-sectional areas (CSA) of left and right internal jugular veins (IJV) were monitored. Self-generated LBNP, which requires mild to moderate physical activity, significantly elevated heart rate and blood pressure (

Indexed as

fluid shiftsLBNPmicrogravitySANSspaceflight

Identifiers

PMID39063548

DOI10.3390/life14070793

PMCPMC11277579

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.