Cramp-Fasciculation Syndrome Associated with Natural and Added Chemicals in Popular Food Items.

Emmeline Lagrange, Jean-Paul Vernoux, Celia Chambon, William Camu, Peter S Spencer

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In one paragraph

Article in Foods (Basel, Switzerland), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

Authors and funding

5 authors.

Emmeline LagrangeDepartment of Neurology, Reference Center of Neuromuscular Disease and ALS Consultations, Grenoble University Hospital, 38043 Grenoble, France.ORCID 0000-0002-9844-0762

Jean-Paul VernouxUnité de Recherche Aliments Bioprocédés Toxicologie Environnements (ABTE) EA 4651, Normandie University, UNICAEN, 14000 Caen, France.ORCID 0000-0001-5841-356X

Celia ChambonDepartment of Neurology, Reference Center of Neuromuscular Disease and ALS Consultations, Grenoble University Hospital, 38043 Grenoble, France.

William CamuThe Neuroscience Institute of Montpellier, Inserm UMR1051, 34000 Montpellier, France.ORCID 0000-0003-1287-7355

Peter S SpencerDepartment of Neurology, School of Medicine, Oregon Health & Science University, Portland, OR 97201, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cramp-fasciculation syndrome (CFS) is a rare and benign neuromuscular disorder that may initially masquerade as motor neuron disease/amyotrophic lateral sclerosis. While CFS may have a familial disposition, we report on cases associated with high consumption of popular food items. One set of patients reversibly experienced acute onset of headache, flushing, muscle stiffness and fasciculations following the consumption of umami-flavored food containing a large concentration of monosodium glutamate. A second group of patients consuming food derived from lupin seed developed acute cholinergic toxicity, CFS, and, with chronic intake, significant, self-limiting, but incompletely reversible upper and lower motor neuron deficits. While these cases may improve our knowledge about the possible causes of CFS, our series also demonstrates that excessive consumption of some popular foods is not harmless. This warrants further research on their safety at all stages of human development from a neurological point of view.

Indexed as

glutamatelupinmotoneuron diseasemuscle cramp–fasciculations

Identifiers

PMID39063341

DOI10.3390/foods13142257

PMCPMC11276323

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