Evidence map›Paper›PMID 39063208›Full record

ArticleInternational journal of molecular sciences2024

Systemic Inflammatory Changes in Spinal Cord Injured Patients after Adding Aquatic Therapy to Standard Physiotherapy Treatment.

María Teresa Agulló-Ortuño, Helena Romay-Barrero, Johan Lambeck, Juan M Blanco-Calonge, Rubén Arroyo-Fernández, Paula Richley Geigle, Raquel Menchero, Gonzalo Melgar Del Corral, Inés Martínez-Galán

Abstract read
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In one paragraph

Article in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

María Teresa Agulló-OrtuñoDepartment of Nursing Physiotherapy and Occupational Therapy, Faculty of Physical Therapy and Nursing, University of Castilla-La Mancha, Avda. Carlos III s/n, 45071 Toledo, Spain.ORCID 0000-0002-7617-6681
Helena Romay-BarreroDepartment of Nursing Physiotherapy and Occupational Therapy, Faculty of Physical Therapy and Nursing, University of Castilla-La Mancha, Avda. Carlos III s/n, 45071 Toledo, Spain.ORCID 0000-0003-2388-2213
Johan LambeckAssociation International Aquatic Therapy Faculty, 7324 Valens, Switzerland.ORCID 0000-0001-9026-3792
Juan M Blanco-CalongeDepartment of Nursing Physiotherapy and Occupational Therapy, Faculty of Physical Therapy and Nursing, University of Castilla-La Mancha, Avda. Carlos III s/n, 45071 Toledo, Spain.
Rubén Arroyo-FernándezDepartment of Nursing Physiotherapy and Occupational Therapy, Faculty of Physical Therapy and Nursing, University of Castilla-La Mancha, Avda. Carlos III s/n, 45071 Toledo, Spain.ORCID 0000-0001-6831-2244
Paula Richley GeigleThe Western North Carolina VA Health Care System (WNCVAHCS), Asheville, NC 28805, USA.
Raquel MencheroResearch Group on Water and Health (GIAS), University of Castilla-La Mancha. Avda. Carlos III s/n, 45071 Toledo, Spain.ORCID 0000-0002-6012-3649
Gonzalo Melgar Del CorralDepartment of Nursing Physiotherapy and Occupational Therapy, Faculty of Physical Therapy and Nursing, University of Castilla-La Mancha, Avda. Carlos III s/n, 45071 Toledo, Spain.ORCID 0000-0001-8212-7168
Inés Martínez-GalánDepartment of Nursing Physiotherapy and Occupational Therapy, Faculty of Physical Therapy and Nursing, University of Castilla-La Mancha, Avda. Carlos III s/n, 45071 Toledo, Spain.

Funding

Junta de Comunidades de Castilla-La Mancha and co-financed by the European Regional De-velopment Fund (ERDF-FEDER, a way to build Europe) SBPLY/19/180501/000250
6 · The paper itself

Abstract

Spinal cord injury (SCI) is a severe medical condition resulting in substantial physiological and functional consequences for the individual. People with SCI are characterised by a chronic, low-grade systemic inflammatory state, which contributes to further undesirable secondary injuries. This study aimed to evaluate the effect of adding aquatic therapy to the standard physiotherapy treatment, implemented in two different schedules, on systemic inflammation in SCI patients. Additionally, the relationship between cytokine blood levels and changes in functionality (measured with the 6MWT, 10MWT, WISCI, BBS, and TUG tests) throughout the study was assessed. A quantitative multiplexed antibody assay was performed to measure the expression level of 20 pro- and anti-inflammatory cytokines in blood samples from SCI patients at three time points: baseline, week 6, and immediately post-intervention (week 12). This study identified a complex signature of five cytokines (IL-12p70, IL-8, MCP-1, IL-1α, and IP10) associated with the time course of the two physiotherapy programs. Two other cytokines (IL-4 and TNF-α) were also associated with the functional recovery of patients. These could be important indicators for SCI prognosis and provide a basis for developing novel targeted therapies.

Indexed as

CytokinesPhysical Therapy ModalitiesSpinal Cord InjuriesAdultFemaleHumansHydrotherapyInflammationMaleMiddle AgedRecovery of FunctionCytokinesaquatic physiotherapycytokinesphysiotherapyspinal cord injurysystemic inflammation

Identifiers

PMID39063208
PMCPMC11277190

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.