MicroRNA-181a Targets GNAI2 and Affects the Proliferation and Induction Ability of Dermal Papilla Cells: The Potential Involvement of the Wnt/β-Catenin Signaling Pathway.

Mingliang He, Xiaoyang Lv, Joram M Mwacharo, Yutao Li, Shanhe Wang, Wei Sun

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Article in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

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1citing papers in PubMed

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3 · Its place in the literature

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1 citing paper in PubMed.

Genome-wide association study reveals candidate genes associated with body weight and wool traits in Ordos fine-wool sheep.Frontiers in veterinary science · 2026
Article

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5 · Who and what money

Authors and funding

6 authors.

Mingliang HeCollege of Animal Science and Technology, Yangzhou University, Yangzhou 225009, China.ORCID 0000-0001-6157-1171

Xiaoyang LvJoint International Research Laboratory of Agriculture and Agri-Product Safety of Ministry of Education of China, Yangzhou University, Yangzhou 225009, China.

Joram M MwacharoInternational Centre for Agricultural Research in the Dry Areas, Addis Ababa 999047, Ethiopia.

Yutao LiCSIRO Agriculture and Food, 306 Carmody Rd, St. Lucia, Brisbane, QLD 4067, Australia.ORCID 0000-0001-9158-9946

Shanhe WangCollege of Animal Science and Technology, Yangzhou University, Yangzhou 225009, China.ORCID 0000-0003-2888-7515

Wei SunCollege of Animal Science and Technology, Yangzhou University, Yangzhou 225009, China.

Funding

the National Natural Science Foundation of China (32172689), the Natural Science Foundation of Jiangsu Province (BK20210810), the Natural Science Foundation of the Jiangsu Higher Education Institutions of China (20KJB230003 and 22KJA230001), Major New Var 32172689,BK20210810,20KJB230003,22KJA230001,PZCZ201739,32061143036,2022D01D47,G2022014148L,(2022) 2-323,KYCX23_3593

6 · The paper itself

Abstract

Wool is generated by hair follicles (HFs), which are crucial in defining the length, diameter, and morphology of wool fibers. However, the regulatory mechanism of HF growth and development remains largely unknown. Dermal papilla cells (DPCs) are a specialized cell type within HFs that play a crucial role in governing the growth and development of HFs. This study aims to investigate the proliferation and induction ability of ovine DPCs to enhance our understanding of the potential regulatory mechanisms underlying ovine HF growth and development. Previous research has demonstrated that microRNA-181a (miR-181a) was differentially expressed in skin tissues with different wool phenotypes, which indicated that miR-181a might play a crucial role in wool morphogenesis. In this study, we revealed that miR-181a inhibited the proliferation and induction ability of ovine DPCs by quantitative Real-time PCR (qRT-PCR), cell counting Kit-8 (CCK-8), 5-ethynyl-2'-deoxyuridine (EdU), flow cytometry, and alkaline phosphatase staining. Then, we also confirmed G protein subunit alpha i2 (

Indexed as

Cell ProliferationHair FollicleMicroRNAsWnt Signaling PathwayAnimalsbeta CateninCells, CulturedDermisGTP-Binding Protein alpha Subunits, Gi-GoSheepWoolbeta CateninGTP-Binding Protein alpha Subunits, Gi-GoMicroRNAsDPCsGNAI2induction abilitymiR-181aproliferationWnt/β-catenin

Identifiers

PMID39063192

DOI10.3390/ijms25147950

PMCPMC11277120

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.