Evidence map›Paper›PMID 39063172›Full record

ArticleInternational journal of molecular sciences2024

Variable Inhibition of DNA Unwinding Rates Catalyzed by the SARS-CoV-2 Helicase Nsp13 by Structurally Distinct Single DNA Lesions.

Ana H Sales, Iwen Fu, Alexander Durandin, Sam Ciervo, Tania J Lupoli, Vladimir Shafirovich, Suse Broyde, Nicholas E Geacintov

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Ana H SalesChemistry Department, New York University, 31 Washington Place, New York, NY 10003, USA.
Iwen FuBiology Department, New York University, 24 Waverly Place, New York, NY 10003, USA.ORCID 0000-0003-2502-2882
Alexander DurandinChemistry Department, New York University, 31 Washington Place, New York, NY 10003, USA.
Sam CiervoChemistry Department, New York University, 31 Washington Place, New York, NY 10003, USA.
Tania J LupoliChemistry Department, New York University, 31 Washington Place, New York, NY 10003, USA.
Vladimir ShafirovichChemistry Department, New York University, 31 Washington Place, New York, NY 10003, USA.
Suse BroydeBiology Department, New York University, 24 Waverly Place, New York, NY 10003, USA.ORCID 0000-0002-3802-7511
Nicholas E GeacintovChemistry Department, New York University, 31 Washington Place, New York, NY 10003, USA.ORCID 0000-0002-7961-2231

Funding

Environmental DNA Lesions and Mutagenesis: Molecular Mechanisms of Lesion Recognition for Repair and Polymerase BypassR01ES025987 · NIEHS · NEW YORK UNIVERSITY · PI BROYDE, SUSE · 2016 to 2025
$3.6M
Recognition of Environmental Carcinogen-DNA lesions by NER ProteinsR01ES024050 · NIEHS · NEW YORK UNIVERSITY · PI GEACINTOV, NICHOLAS E · 2014 to 2018
$1.8M
Excision of Carcinogen-DNA Adducts in NucleosomesR01CA168469 · NCI · NEW YORK UNIVERSITY · PI GEACINTOV, NICHOLAS E · 2012 to 2016
$1.6M
National Cancer Institute Grant R01-CA168469NIEHS NIH HHS R01 ES025987the National Institute of Environmental Health Sciences Grants R01-ES024050the National Institute of Environmental Health Sciences Grants R01-ES025987
6 · The paper itself

Abstract

The SARS-CoV-2 helicase, non-structural protein 13 (Nsp13), plays an essential role in viral replication, translocating in the 5' → 3' direction as it unwinds double-stranded RNA/DNA. We investigated the impact of structurally distinct DNA lesions on DNA unwinding catalyzed by Nsp13. The selected lesions include two benzo[

Indexed as

DNA HelicasesSARS-CoV-2Viral Nonstructural ProteinsCOVID-19DNADNA DamageHumansKineticsMethyltransferasesRNA HelicasesDNADNA HelicasesMethyltransferasesNsp13 protein, SARS-CoVRNA HelicasesViral Nonstructural Proteins6–4PPbenzo[a]pyrene diol epoxide–DNA adductsCPDcrosslinked thymine dimerNsp13 helicaseprocessivityprotein–DNA interactionsSARS-CoV-2SF1 helicaseunwindingUV photolesions

Identifiers

PMID39063172
PMCPMC11276626

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.