Evidence map›Paper›PMID 39063027›Full record

ArticleInternational journal of molecular sciences2024

Uncovering the Molecular Pathways Implicated in the Anti-Cancer Activity of the Imidazoquinoxaline Derivative EAPB02303 Using a

Perla Makhoul, Simon Galas, Stéphanie Paniagua-Gayraud, Carine Deleuze-Masquefa, Hiba El Hajj, Pierre-Antoine Bonnet, Myriam Richaud

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Perla MakhoulInstitut des Biomolécules Max Mousseron (IBMM), UMR 5247, CNRS, ENSCM, Université de Montpellier, 34090 Montpellier, France.ORCID 0009-0008-3114-7888
Simon GalasInstitut des Biomolécules Max Mousseron (IBMM), UMR 5247, CNRS, ENSCM, Université de Montpellier, 34090 Montpellier, France.ORCID 0000-0002-1717-1266
Stéphanie Paniagua-GayraudInstitut des Biomolécules Max Mousseron (IBMM), UMR 5247, CNRS, ENSCM, Université de Montpellier, 34090 Montpellier, France.
Carine Deleuze-MasquefaInstitut des Biomolécules Max Mousseron (IBMM), UMR 5247, CNRS, ENSCM, Université de Montpellier, 34090 Montpellier, France.
Hiba El HajjDepartment of Experimental Pathology, Immunology and Microbiology, Faculty of Medicine, American University of Beirut, Riad El-Solh, P.O. Box 11-0236, Beirut 1107, Lebanon.ORCID 0000-0002-1069-0477
Pierre-Antoine BonnetInstitut des Biomolécules Max Mousseron (IBMM), UMR 5247, CNRS, ENSCM, Université de Montpellier, 34090 Montpellier, France.
Myriam RichaudInstitut des Biomolécules Max Mousseron (IBMM), UMR 5247, CNRS, ENSCM, Université de Montpellier, 34090 Montpellier, France.ORCID 0000-0002-7720-8569

Funding

French National Research Agency ANR ANR-16-IDEX-006
6 · The paper itself

Abstract

Imiqualines are analogues of the immunomodulatory drug imiquimod. EAPB02303, the lead of the second-generation imiqualines, is characterized by significant anti-tumor effects with IC50s in the nanomolar range. We used

Indexed as

Antineoplastic AgentsCaenorhabditis elegansCaenorhabditis elegans ProteinsForkhead Transcription FactorsQuinoxalinesSignal TransductionAnimalsAnimals, Genetically ModifiedHumansImidazolesLongevityPhosphatidylinositol 3-KinasesProto-Oncogene Proteins c-aktAntineoplastic AgentsCaenorhabditis elegans Proteinsdaf-16 protein, C elegansForkhead Transcription FactorsImidazolesPhosphatidylinositol 3-KinasesProto-Oncogene Proteins c-aktQuinoxalinesCaenorhabditis eleganscancerDAF-16/FOXOIIS pathwayimiqualinesLET-60/RasPI3K-AktRas-MAPK pathway

Identifiers

PMID39063027
PMCPMC11277376

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.