Evidence map›Paper›PMID 39063000›Full record

ArticleInternational journal of molecular sciences2024

The Inflammasome Adaptor Protein ASC in Plasma as a Biomarker of Early Cognitive Changes.

Brianna Cyr, Rosie Curiel Cid, David Loewenstein, Regina T Vontell, W Dalton Dietrich, Robert W Keane, Juan Pablo de Rivero Vaccari

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Brianna CyrThe Miami Project to Cure Paralysis, Department of Neurological Surgery, University of Miami, Miami, FL 33136, USA.ORCID 0000-0002-2924-7416
Rosie Curiel CidCenter for Cognitive Neuroscience and Aging, University of Miami, Miami, FL 33136, USA.
David LoewensteinCenter for Cognitive Neuroscience and Aging, University of Miami, Miami, FL 33136, USA.
Regina T VontellDepartment of Neurology, University of Miami, Miami, FL 33136, USA.ORCID 0000-0002-2664-8265
W Dalton DietrichThe Miami Project to Cure Paralysis, Department of Neurological Surgery, University of Miami, Miami, FL 33136, USA.
Robert W KeaneThe Miami Project to Cure Paralysis, Department of Neurological Surgery, University of Miami, Miami, FL 33136, USA.ORCID 0000-0003-4068-9511
Juan Pablo de Rivero VaccariThe Miami Project to Cure Paralysis, Department of Neurological Surgery, University of Miami, Miami, FL 33136, USA.ORCID 0000-0002-5460-8834

Funding

The Importance of Abnormal Inflammasome Activation as a Risk Factor between Traumatic Brain Injury and Alzheimer’s DiseaseRF1NS125578 · NINDS · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI DE RIVERO VACCARI, JUAN PABLO, DIETRICH, W DALTON · 2021 to 2023
$2.8M
Role of ASC in TBI-Mediated Systemic Inflammation.R01NS113969 · NINDS · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI DE RIVERO VACCARI, JUAN PABLO, KEANE, ROBERT W · 2020 to 2024
$1.9M
Human Schwann Cell-Derived Exosome Treatment for Traumatic Brain InjuryR37NS133195 · NINDS · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI W Dalton Dietrich · 2023 to 2026
$1.7M
NIH HHS 1RF1NS125578-01NIH HHS R01NS113969NINDS NIH HHS R37 NS133195NINDS NIH HHS RF1 NS125578
6 · The paper itself

Abstract

Dementia is a group of symptoms including memory loss, language difficulties, and other types of cognitive and functional impairments that affects 57 million people worldwide, with the incidence expected to double by 2040. Therefore, there is an unmet need to develop reliable biomarkers to diagnose early brain impairments so that emerging interventions can be applied before brain degeneration. Here, we performed biomarker analyses for apoptosis-associated speck-like protein containing a caspase recruitment domain (ASC), neurofilament light chain (NfL), glial fibrillary acidic protein (GFAP), and amyloid-β 42/40 (Aβ

Indexed as

Amyloid beta-PeptidesBiomarkersCARD Signaling Adaptor ProteinsCognitive DysfunctionAgedAged, 80 and overFemaleGlial Fibrillary Acidic ProteinHumansInflammasomesMaleNeurofilament ProteinsPeptide FragmentsAmyloid beta-Peptidesamyloid beta-protein (1-42)BiomarkersCARD Signaling Adaptor ProteinsGFAP protein, humanGlial Fibrillary Acidic ProteinInflammasomesneurofilament protein LNeurofilament ProteinsPeptide FragmentsPYCARD protein, humanAlzheimer’s diseaseASCAβ42biomarkerinflammaginginflammasomemild cognitive impairmentPYCARD

Identifiers

PMID39063000
PMCPMC11276719

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.