Evidence map›Paper›PMID 39062971›Full record

ReviewInternational journal of molecular sciences2024

Neuroblastoma-A Review of Combination Immunotherapy.

Barbara Pieniążek, Katarzyna Cencelewicz, Patrycja Bździuch, Łukasz Młynarczyk, Monika Lejman, Joanna Zawitkowska, Katarzyna Derwich

Registry-linked trialAbstract readReview
In one paragraph

Review in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07278674 (Clinical Study of Eflornithine After Immunotherapy for High-risk Neuroblastoma(CSHEIN)), which is not on this map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07278674 active not recruitingnot on this mapstarted 2025, after this paper: background citation

Clinical Study of Eflornithine After Immunotherapy for High-risk Neuroblastoma(CSHEIN)

Typeobservational_patient_registrySponsorShanghai Children's HospitalRan2025 to 2029Enrolled20ConditionsHigh Risk NeuroblastomaArmsOral administration of eflornithine for the prevention of high-risk neuroblastoma
3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Review
  7. Article
  8. Article
  9. Article
  10. Review
  11. Article
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Barbara PieniążekStudent Scientific Society of Department of Pediatric Hematology, Oncology and Transplantology, Medical University of Lublin, 20-093 Lublin, Poland.ORCID 0009-0009-9051-9503
Katarzyna CencelewiczStudent Scientific Society of Department of Pediatric Hematology, Oncology and Transplantology, Medical University of Lublin, 20-093 Lublin, Poland.ORCID 0009-0000-5318-4606
Patrycja BździuchStudent Scientific Society of Department of Pediatric Hematology, Oncology and Transplantology, Medical University of Lublin, 20-093 Lublin, Poland.ORCID 0009-0007-6830-0287
Łukasz MłynarczykDepartment of Pediatric Oncology, Hematology and Transplantology, Poznan University of Medical Sciences, 60-572 Poznań, Poland.ORCID 0009-0005-2979-0493
Monika LejmanIndependent Laboratory of Genetic Diagnostics, Medical University of Lublin, 20-093 Lublin, Poland.ORCID 0000-0002-8760-0775
Joanna ZawitkowskaDepartment of Pediatric Hematology, Oncology and Transplantation, Medical University of Lublin, 20-093 Lublin, Poland.ORCID 0000-0001-7207-156X
Katarzyna DerwichDepartment of Pediatric Oncology, Hematology and Transplantology, Poznan University of Medical Sciences, 60-572 Poznań, Poland.ORCID 0000-0001-7239-4035

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Neuroblastoma is the most common extracranial solid tumor found in childhood and is responsible for 15% of deaths among children with cancer. Although multimodal therapies focused on surgery, chemotherapy, radiotherapy, and stem cell transplants have favorable results in many cases, the use of conventional therapies has probably reached the limit their possibility. Almost half of the patients with neuroblastoma belong to the high-risk group. Patients in this group require a combination of several therapeutic approaches. It has been shown that various immunotherapies combined with conventional methods can work synergistically. Due to the development of such therapeutic methods, we present combinations and forms of combining immunotherapy, focusing on their mechanisms and benefits but also their limitations and potential side effects.

Indexed as

ImmunotherapyNeuroblastomaAnimalsCombined Modality TherapyHumanscancercombining therapyimmunotherapyneuroblastomapediatric oncology

Identifiers

PMID39062971
PMCPMC11276848

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.