Evidence map›Paper›PMID 39062952›Full record

ArticleInternational journal of molecular sciences2024

Gastrodin Improves the Activity of the Ubiquitin-Proteasome System and the Autophagy-Lysosome Pathway to Degrade Mutant Huntingtin.

He Sun, Miao Li, Yunling Li, Na Zheng, Jiaxin Li, Xiang Li, Yingying Liu, Qianyun Ji, Liping Zhou, Jingwen Su and 4 more

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Comparative Phytochemical Analysis ofMolecules (Basel, Switzerland) · 2025
    Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

He SunDepartment of Pharmacology, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenhe District, Shenyang 110016, China.
Miao LiDepartment of Pharmacology, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenhe District, Shenyang 110016, China.
Yunling LiWuya College of Innovation, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenhe District, Shenyang 110016, China.
Na ZhengDepartment of Pharmacology, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenhe District, Shenyang 110016, China.
Jiaxin LiDepartment of Bioengineering, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenhe District, Shenyang 110016, China.
Xiang LiDepartment of Medicinal Chemistry, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenhe District, Shenyang 110016, China.
Yingying LiuDepartment of Pharmacology, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenhe District, Shenyang 110016, China.
Qianyun JiDepartment of Pharmacology, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenhe District, Shenyang 110016, China.
Liping ZhouDepartment of Pharmacology, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenhe District, Shenyang 110016, China.
Jingwen SuSchool of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenhe District, Shenyang 110016, China.
Wanxu HuangWuya College of Innovation, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenhe District, Shenyang 110016, China.
Zhongbo LiuSchool of Pharmacy, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenhe District, Shenyang 110016, China.
Peng LiuDepartment of Pharmacology, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenhe District, Shenyang 110016, China.ORCID 0000-0002-5469-4031
Libo ZouDepartment of Pharmacology, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenhe District, Shenyang 110016, China.

Funding

Career Development Program for Young Teachers of Shenyang Pharmaceutical University ZQN2021004Innovation and Entrepreneurship Training Program for College Students of Shenyang Pharmaceutical University 202210163021Innovation and Entrepreneurship Training Program for College Students of Shenyang Pharmaceutical University S202310163038Natural Science Foundation of Liaoning Province 2021-MS-212Scientific Research Funding Project of Liaoning Provincial Department of Education LJKZ0914
6 · The paper itself

Abstract

Gastrodin (GAS) is the main chemical component of the traditional Chinese herb

Indexed as

AutophagyBenzyl AlcoholsGlucosidesHuntingtin ProteinLysosomesProteasome Endopeptidase ComplexUbiquitinAnimalsHuntington DiseaseMiceMutationPC12 CellsProteolysisRatsBenzyl AlcoholsgastrodinGlucosidesHuntingtin ProteinProteasome Endopeptidase ComplexUbiquitinautophagy–lysosome pathwaygastrodinmutant huntingtin proteinneurodegenerationubiquitin–proteasome system

Identifiers

PMID39062952
PMCPMC11277377

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.