Evidence map›Paper›PMID 39062946›Full record

ArticleInternational journal of molecular sciences2024

The Variation in the Traits Ameliorated by Inhibitors of JAK1/2, TGF-β, P-Selectin, and CXCR1/CXCR2 in the

Francesca Gobbo, Fabrizio Martelli, Antonio Di Virgilio, Elena Demaria, Giuseppe Sarli, Anna Rita Migliaccio

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Francesca GobboDepartment of Veterinary Medical Sciences, Alma Mater Studiorum University, 40126 Bologna, Italy.ORCID 0000-0002-4082-4675
Fabrizio MartelliNational Center for Drug Research and Evaluation, Istituto Superiore di Sanità, 00161 Rome, Italy.ORCID 0000-0002-7811-242X
Antonio Di VirgilioNational Center for Drug Research and Evaluation, Istituto Superiore di Sanità, 00161 Rome, Italy.
Elena DemariaDepartment of Medical and Surgical Sciences, Alma Mater Studiorum University, 40126 Bologna, Italy.ORCID 0009-0007-3683-0232
Giuseppe SarliDepartment of Veterinary Medical Sciences, Alma Mater Studiorum University, 40126 Bologna, Italy.ORCID 0000-0001-6405-3484
Anna Rita MigliaccioAltius Institute for Biomedical Sciences, Seattle, WA 98121, USA.

Funding

Tissue BankP01CA108671 · NCI · UNIVERSITY OF ILLINOIS AT CHICAGO · PI Ross L Levine · 2006 to 2026
$82.0M
AIRC (Associazione Italiana Ricerca Cancro) IG23525Natinall Cancer Institute P01-CA108671NCI NIH HHS P01 CA108671
6 · The paper itself

Abstract

Studies conducted on animal models have identified several therapeutic targets for myelofibrosis, the most severe of the myeloproliferative neoplasms. Unfortunately, many of the drugs which were effective in pre-clinical settings had modest efficacy when tested in the clinic. This discrepancy suggests that treatment for this disease requires combination therapies. To rationalize possible combinations, the efficacy in the

Indexed as

Janus Kinase 1Primary MyelofibrosisP-SelectinPyrimidinesReceptors, Interleukin-8BTransforming Growth Factor betaAnimalsDisease Models, AnimalDrug Therapy, CombinationGATA1 Transcription FactorHumansJanus Kinase 2MiceNitrilesPyrazolesReceptors, Interleukin-8AGATA1 Transcription FactorJanus Kinase 1Janus Kinase 2NitrilesP-SelectinPyrazolesPyrimidinesReceptors, Interleukin-8AReceptors, Interleukin-8BruxolitinibTransforming Growth Factor betaGata1IL-8megakaryocytesmyelofibrosisP-selectinTGF-β

Identifiers

PMID39062946
PMCPMC11277099

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.