Evidence map›Paper›PMID 39062862›Full record

ArticleInternational journal of molecular sciences2024

Mutations in Genes Encoding Subunits of the RNA Exosome as a Potential Novel Cause of Thrombotic Microangiopathy.

Kioa L Wijnsma, Anne M Schijvens, Romy N Bouwmeester, Lonneke A M Aarts, Lambertus Bert P van den Heuvel, Charlotte A Haaxma, Nicole C A J van de Kar

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PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Kioa L WijnsmaDepartment of Pediatric Nephrology, Amalia Children's Hospital, Radboud University Medical Center, 6525 GA Nijmegen, The Netherlands.ORCID 0000-0003-0019-109X
Anne M SchijvensDepartment of Pediatric Nephrology, Amalia Children's Hospital, Radboud University Medical Center, 6525 GA Nijmegen, The Netherlands.
Romy N BouwmeesterDepartment of Pediatric Nephrology, Amalia Children's Hospital, Radboud University Medical Center, 6525 GA Nijmegen, The Netherlands.
Lonneke A M AartsDepartment of Pediatrics, Amalia Children's Hospital, Radboud University Medical Center, 6525 GA Nijmegen, The Netherlands.
Lambertus Bert P van den HeuvelDepartment of Pediatric Nephrology, Amalia Children's Hospital, Radboud University Medical Center, 6525 GA Nijmegen, The Netherlands.
Charlotte A HaaxmaDepartment of Pediatric Neurology, Amalia Children's Hospital, Radboud University Medical Center, 6525 GA Nijmegen, The Netherlands.ORCID 0000-0002-0682-345X
Nicole C A J van de KarDepartment of Pediatric Nephrology, Amalia Children's Hospital, Radboud University Medical Center, 6525 GA Nijmegen, The Netherlands.ORCID 0000-0002-1990-1189

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Thrombotic microangiopathy (TMA) in association with RNA exosome encoding mutations has only recently been recognized. Here, we present an infant (female) with an

Indexed as

Exosome Multienzyme Ribonuclease ComplexMutationThrombotic MicroangiopathiesAntibodies, Monoclonal, HumanizedExosomesFemaleHumansInfantRNA-Binding ProteinsAntibodies, Monoclonal, HumanizedeculizumabEXOSC3 protein, humanExosome Multienzyme Ribonuclease ComplexRNA-Binding Proteinshemolytic uremic syndromeRNA exosomethrombotic microangiopathy

Identifiers

PMID39062862
PMCPMC11277116

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.