Evidence map›Paper›PMID 39062841›Full record

ArticleInternational journal of molecular sciences2024

Approach for Phased Sequence-Based Genotyping of the Critical Pharmacogene Dihydropyrimidine Dehydrogenase (

Alisa Ambrodji, Angélique Sadlon, Ursula Amstutz, Dennis Hoch, Martin D Berger, Sara Bastian, Steven M Offer, Carlo R Largiadèr

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Preventing adverse drug reactions and more: current clinical use of pharmacogenetic testing.Medizinische Genetik : Mitteilungsblatt des Berufsverbandes Medizinische Genetik e.V · 2025
    Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Alisa AmbrodjiDepartment of Clinical Chemistry, Inselspital, University Hospital of Bern, University of Bern, INO-F, 3010 Bern, Switzerland.ORCID 0009-0000-5597-0360
Angélique SadlonDepartment of Clinical Chemistry, Inselspital, University Hospital of Bern, University of Bern, INO-F, 3010 Bern, Switzerland.
Ursula AmstutzDepartment of Clinical Chemistry, Inselspital, University Hospital of Bern, University of Bern, INO-F, 3010 Bern, Switzerland.
Dennis HochDepartment of Medical Oncology, Inselspital, University Hospital of Bern, 3010 Bern, Switzerland.
Martin D BergerDepartment of Medical Oncology, Inselspital, University Hospital of Bern, 3010 Bern, Switzerland.
Sara BastianDepartment of Medical Oncology, Cantonal Hospital Graubünden, 7000 Chur, Switzerland.ORCID 0000-0003-2848-9162
Steven M OfferDepartment of Pathology, Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA.ORCID 0000-0002-7513-9678
Carlo R LargiadèrDepartment of Clinical Chemistry, Inselspital, University Hospital of Bern, University of Bern, INO-F, 3010 Bern, Switzerland.ORCID 0000-0002-0889-8922

Funding

A precision medicine approach to improve prediction of severe toxicity in fluorouracil chemotherapy (Diversity Supplement)R01CA251065 · NCI · UNIVERSITY OF IOWA · PI Steven Offer · 2021 to 2026
$2.1M
NCI NIH HHS R01 CA251065Swiss National Science Foundation 320030_212583
6 · The paper itself

Abstract

Pre-treatment genotyping of four well-characterized toxicity risk-variants in the dihydropyrimidine dehydrogenase gene (

Indexed as

Dihydrouracil Dehydrogenase (NADP)GenotypeGenotyping TechniquesAllelesHigh-Throughput Nucleotide SequencingHumansNeoplasmsPolymorphism, Single NucleotideSequence Analysis, DNADihydrouracil Dehydrogenase (NADP)compound heterozygousDPYDfluoropyrimidineshaplotypelong-range ampliconOxford Nanopore Technologies sequencingPCR chimerapharmacogenomicsrare variants

Identifiers

PMID39062841
PMCPMC11277299

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.