Evidence map›Paper›PMID 39062794›Full record

ArticleInternational journal of molecular sciences2024

Identifying Diagnostic Markers and Constructing Predictive Models for Oxidative Stress in Multiple Sclerosis.

Yantuanjin Ma, Fang Wang, Qiting Zhao, Lili Zhang, Shunmei Chen, Shufen Wang

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Yantuanjin MaInstitute of Biomedical Engineering, Kunming Medical Univesity, Kunming 650500, China.ORCID 0000-0003-4714-2391
Fang WangDepartment of Science and Technology, Kunming Medical University, Kunming 650500, China.
Qiting ZhaoInstitute of Biomedical Engineering, Kunming Medical Univesity, Kunming 650500, China.
Lili ZhangInstitute of Biomedical Engineering, Kunming Medical Univesity, Kunming 650500, China.
Shunmei ChenInstitute of Biomedical Engineering, Kunming Medical Univesity, Kunming 650500, China.
Shufen WangInstitute of Biomedical Engineering, Kunming Medical Univesity, Kunming 650500, China.

Funding

the National Natural Science Foundation of China 81560215the National Natural Science Foundation of China 81960240The Yunnan Provincial Science and Technology Department-Kunming Medical University joint projects 202001AY070001-001The Yunnan Provincial Science and Technology Department-Kunming Medical University joint projects 202101AY070001-073
6 · The paper itself

Abstract

Multiple sclerosis (MS) is a chronic disease characterized by inflammation and neurodegeneration of the central nervous system. Despite the significant role of oxidative stress in the pathogenesis of MS, its precise molecular mechanisms remain unclear. This study utilized microarray datasets from the GEO database to analyze differentially expressed oxidative-stress-related genes (DE-OSRGs), identifying 101 DE-OSRGs. Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) analyses indicate that these genes are primarily involved in oxidative stress and immune responses. Through protein-protein interaction (PPI) network, LASSO regression, and logistic regression analyses, four genes (

Indexed as

BiomarkersMultiple SclerosisOxidative StressAnimalsDisease Models, AnimalEncephalomyelitis, Autoimmune, ExperimentalGene Expression ProfilingGene OntologyHumansMiceMolecular Docking SimulationProtein Interaction MapsBiomarkersdiagnostic biomarkersimmune cell infiltrationmolecular dockingmultiple sclerosisoxidative stress

Identifiers

PMID39062794
PMCPMC11276709

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.