Evidence map›Paper›PMID 39062779›Full record

Trial reportInternational journal of molecular sciences2024

Controlled Hypoxia Acutely Prevents Physical Inactivity-Induced Peripheral BDNF Decline.

Yves Duderstadt, Stefanie Schreiber, Johannes Burtscher, Lutz Schega, Notger G Müller, Tanja Brigadski, Rüdiger C Braun-Dullaeus, Volkmar Leßmann, Patrick Müller

Abstract readRandomized Controlled Trial
In one paragraph

Trial report in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Yves DuderstadtDivision of Cardiology and Angiology, University Hospital Magdeburg, 39120 Magdeburg, Germany.ORCID 0000-0001-9031-5943
Stefanie SchreiberGerman Center for Neurodegenerative Diseases (DZNE), 39120 Magdeburg, Germany.ORCID 0000-0003-4439-4374
Johannes BurtscherInstitute of Sports Science, University Innsbruck, 6020 Innsbruck, Austria.ORCID 0000-0002-2889-0151
Lutz SchegaDepartment of Sports Science, Chair of Health and Physical Activity, Otto-von-Guericke University, 39104 Magdeburg, Germany.ORCID 0000-0003-0421-0796
Notger G MüllerGerman Center for Neurodegenerative Diseases (DZNE), 39120 Magdeburg, Germany.
Tanja BrigadskiInstitute of Physiology, Otto-von-Guericke University, 39120 Magdeburg, Germany.
Rüdiger C Braun-DullaeusDivision of Cardiology and Angiology, University Hospital Magdeburg, 39120 Magdeburg, Germany.ORCID 0000-0003-3888-6532
Volkmar LeßmannCenter for Intervention and Research on Adaptive and Maladaptive Brain Circuits Underlying Mental Health (C-I-R-C), 39120 Magdeburg, Germany.ORCID 0000-0002-6863-323X
Patrick MüllerDivision of Cardiology and Angiology, University Hospital Magdeburg, 39120 Magdeburg, Germany.

Funding

Otto-von-Guericke-University Magdeburg, Germany PLP23/5Supported by German Center for Mental Health (DZPG) funded by BMBF and Federal State Saxony-Anhalt to V.L. FKZ: 01EE2305D
6 · The paper itself

Abstract

Brain-derived neurotrophic factor (BDNF) is a crucial mediator of neuronal plasticity. Here, we investigated the effects of controlled normobaric hypoxia (NH) combined with physical inactivity on BDNF blood levels and executive functions. A total of 25 healthy adults (25.8 ± 3.3 years, 15 female) were analyzed in a randomized controlled cross-over study. Each intervention began with a 30 min resting phase under normoxia (NOR), followed by a 90 min continuation of NOR or NH (peripheral oxygen saturation [SpO

Indexed as

Brain-Derived Neurotrophic FactorHeart RateHypoxiaSedentary BehaviorAdultCross-Over StudiesExerciseFemaleHumansMaleYoung AdultBDNF protein, humanBrain-Derived Neurotrophic FactorBDNFcognitionhypoxiaphysical inactivity

Identifiers

PMID39062779
PMCPMC11276956

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.