Evidence map›Paper›PMID 39062759›Full record

ArticleInternational journal of molecular sciences2024

Synthesis and Biological Evaluation of Novel 2-Aroyl Benzofuran-Based Hydroxamic Acids as Antimicrotubule Agents.

Elena Mariotto, Martina Canton, Chiara Marchioro, Andrea Brancale, Ernest Hamel, Katia Varani, Fabrizio Vincenzi, Tiziano De Ventura, Chiara Padroni, Giampietro Viola and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Elena MariottoDepartment of Woman's and Child's Health, Hemato-Oncology Lab, University of Padova, 35128 Padova, Italy.ORCID 0000-0002-3960-8561
Martina CantonDepartment of Woman's and Child's Health, Hemato-Oncology Lab, University of Padova, 35128 Padova, Italy.ORCID 0000-0002-0532-4157
Chiara MarchioroDepartment of Woman's and Child's Health, Hemato-Oncology Lab, University of Padova, 35128 Padova, Italy.ORCID 0000-0002-5863-8432
Andrea BrancaleDepartment of Organic Chemistry, University of Chemistry and Technology, Prague, 166 28 Prague, Czech Republic.
Ernest HamelMolecular Pharmacology Branch, Developmental Therapeutics Program, Division of Cancer Treatment and Diagnosis, Frederick National Laboratory for Cancer Research, National Cancer Institute, National Institutes of Health, Frederick, MD 21702, USA.
Katia VaraniDepartment of Translational Medicine, University of Ferrara, 44121 Ferrara, Italy.ORCID 0000-0003-4562-1348
Fabrizio VincenziDepartment of Translational Medicine, University of Ferrara, 44121 Ferrara, Italy.ORCID 0000-0002-5027-1699
Tiziano De VenturaDepartment of Chemical, Pharmaceutical and Agricultural Sciences, University of Ferrara, 44121 Ferrara, Italy.
Chiara PadroniMedicinal Chemistry Department, Integrated Drug Discovery, Aptuit, an Evotec Company, 37135 Verona, Italy.
Giampietro ViolaDepartment of Woman's and Child's Health, Hemato-Oncology Lab, University of Padova, 35128 Padova, Italy.ORCID 0000-0001-9329-165X
Romeo RomagnoliDepartment of Chemical, Pharmaceutical and Agricultural Sciences, University of Ferrara, 44121 Ferrara, Italy.ORCID 0000-0002-6374-773X

Funding

University of Ferrara 2022-FAR.L-RR_044
6 · The paper itself

Abstract

Because of synergism between tubulin and HDAC inhibitors, we used the pharmacophore fusion strategy to generate potential tubulin-HDAC dual inhibitors. Drug design was based on the introduction of a

Indexed as

Antineoplastic AgentsBenzofuransCell ProliferationHydroxamic AcidsTubulinTubulin ModulatorsCell Line, TumorDrug Screening Assays, AntitumorHeLa CellsHistone Deacetylase 6Histone Deacetylase InhibitorsHT29 CellsHumansMCF-7 CellsStructure-Activity RelationshipAntineoplastic AgentsbenzofuranBenzofuransHistone Deacetylase 6Histone Deacetylase InhibitorsHydroxamic AcidsTubulinTubulin Modulatorsanticancer agentsbenzo[b]furandual-target inhibitorshistone deacetylase (HDAC)tubulin

Identifiers

PMID39062759
PMCPMC11277476

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.