Evidence map›Paper›PMID 39062523›Full record

ArticleBiomolecules2024

West Nile Virus-Induced Expression of Senescent Gene

Artem Arutyunov, Violeta Durán-Laforet, Shenjian Ai, Loris Ferrari, Robert Murphy, Dorothy P Schafer, Robyn S Klein

Abstract read
In one paragraph

Article in Biomolecules, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Article
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  5. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Artem ArutyunovCenter for Neuroimmunology & Neuroinfectious Diseases, St. Louis, MO 63110, USA.ORCID 0000-0001-5701-2158
Violeta Durán-LaforetDepartment of Neurobiology, Brudnick Neuropsychiatric Research Institute, University of Massachusetts Chan Medical School, Worcester, MA 01655, USA.ORCID 0000-0002-1679-4744
Shenjian AiCenter for Neuroimmunology & Neuroinfectious Diseases, St. Louis, MO 63110, USA.ORCID 0000-0002-9433-8939
Loris FerrariDepartment of Neurobiology, Brudnick Neuropsychiatric Research Institute, University of Massachusetts Chan Medical School, Worcester, MA 01655, USA.
Robert MurphyDepartment of Neurobiology, Brudnick Neuropsychiatric Research Institute, University of Massachusetts Chan Medical School, Worcester, MA 01655, USA.
Dorothy P SchaferDepartment of Neurobiology, Brudnick Neuropsychiatric Research Institute, University of Massachusetts Chan Medical School, Worcester, MA 01655, USA.
Robyn S KleinDepartment of Microbiology & Immunology, Western Institute of Neuroscience, Schulich School of Medicine & Dentistry, University of Western Ontario, 100 Perth Dr, London, ON N6A 5K8, Canada.

Funding

Research Program Award (R35 Clinical Trial Optional) - Dr. Robyn Klein NINDSR35NS122310 · NINDS · WASHINGTON UNIVERSITY · PI CAIN, MATTHEW D · 2021 to 2024
$3.7M
How Do Synaptic Connections Change in Demyelinating Disease?R01NS117533 · NINDS · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI SCHAFER, DOROTHY PATRICIA · 2021 to 2025
$2.2M
Dissecting the impact of senescence on microglia function and neurodegenerationR01AG068281 · NIA · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI SCHAFER, DOROTHY PATRICIA, ZHANG, HONG · 2024 to 2024
$419k
NIA NIH HHS R01 AG068281NIH HHS 1R35NS122310-23A2NINDS NIH HHS R01 NS117533NINDS NIH HHS R35 NS122310NINDS NIH HHS R35NS122310
6 · The paper itself

Abstract

Microglia, the resident macrophages of the central nervous system, exhibit altered gene expression in response to various neurological conditions. This study investigates the relationship between West Nile Virus infection and microglial senescence, focusing on the role of LGALS3BP, a protein implicated in both antiviral responses and aging. Using spatial transcriptomics, RNA sequencing and flow cytometry, we characterized changes in microglial gene signatures in adult and aged mice following recovery from WNV encephalitis. Additionally, we analyzed

Indexed as

Cerebral CortexGlycoproteinsMicrogliaWest Nile FeverWest Nile virusAgingAnimalsCarrier ProteinsCellular SenescenceMaleMiceMice, Inbred C57BLMice, KnockoutPhenotypeCarrier ProteinsGlycoproteinsPpicap protein, mouseagingCD8 T cellflavivirus encephalitisLgals3Lgals3bpmicrogliamicroglia transcriptomicsneurodegenerationneuroinfectious diseasesenescenceWest Nile virus

Identifiers

PMID39062523
PMCPMC11274721

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.