Evidence map›Paper›PMID 39062181›Full record

ArticleBiomedicines2024

Analysis of Ferritin, Hepcidin, Zinc, C-Reactive Protein and IL-6 Levels in COVID-19 in Patients Living at Different Altitudes in Peru.

Wilmer Silva-Caso, Sungmin Kym, Alfredo Merino-Luna, Miguel Angel Aguilar-Luis, Yordi Tarazona-Castro, Hugo Carrillo-Ng, Eliezer Bonifacio-Velez de Villa, Ronald Aquino-Ortega, Juana Del Valle-Mendoza

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomedicines, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Wilmer Silva-CasoBiomedicine Laboratory, Research Center of the Faculty of Health Sciences, Universidad Peruana de Ciencias Aplicadas, Av. San Marcos Cuadra 2, Chorrillos, Lima 15023, Peru.
Sungmin KymDivision of Infectious Disease, Department of Internal Medicine, Chungnam National University School of Medicine, Daejeon 305764, Republic of Korea.
Alfredo Merino-LunaUnidad de Cuidados Intensivos, Clinica San Pablo, Sede Huaraz, Huaraz 02002, Peru.ORCID 0000-0002-9575-1813
Miguel Angel Aguilar-LuisBiomedicine Laboratory, Research Center of the Faculty of Health Sciences, Universidad Peruana de Ciencias Aplicadas, Av. San Marcos Cuadra 2, Chorrillos, Lima 15023, Peru.ORCID 0000-0001-7023-3190
Yordi Tarazona-CastroBiomedicine Laboratory, Research Center of the Faculty of Health Sciences, Universidad Peruana de Ciencias Aplicadas, Av. San Marcos Cuadra 2, Chorrillos, Lima 15023, Peru.ORCID 0000-0003-0740-4502
Hugo Carrillo-NgBiomedicine Laboratory, Research Center of the Faculty of Health Sciences, Universidad Peruana de Ciencias Aplicadas, Av. San Marcos Cuadra 2, Chorrillos, Lima 15023, Peru.
Eliezer Bonifacio-Velez de VillaBiomedicine Laboratory, Research Center of the Faculty of Health Sciences, Universidad Peruana de Ciencias Aplicadas, Av. San Marcos Cuadra 2, Chorrillos, Lima 15023, Peru.ORCID 0000-0003-3589-4617
Ronald Aquino-OrtegaBiomedicine Laboratory, Research Center of the Faculty of Health Sciences, Universidad Peruana de Ciencias Aplicadas, Av. San Marcos Cuadra 2, Chorrillos, Lima 15023, Peru.ORCID 0000-0002-9100-8547
Juana Del Valle-MendozaBiomedicine Laboratory, Research Center of the Faculty of Health Sciences, Universidad Peruana de Ciencias Aplicadas, Av. San Marcos Cuadra 2, Chorrillos, Lima 15023, Peru.

Funding

Korea Health Industry Development Institute HI22C0594Peruvian University of Applied Sciences UPC- C-010-2021-2
6 · The paper itself

Abstract

backgroundDespite great scientific efforts, understanding the role of COVID-19 clinical biomarkers remains a challenge.

methodsA cross-sectional descriptive study in two Peruvian cities at different altitudes for comparison: Lima and Huaraz. In each place, three groups were formed, made up of 25 patients with COVID-19 in the ICU, 25 hospitalized patients with COVID-19 who did not require the ICU, and 25 healthy subjects as a control group. Five biomarkers were measured: IL-6, hepcidin, ferritin, C-reactive protein, and zinc using ELISA assays.

resultsFerritin, C-reactive protein, and IL-6 levels were significantly higher in the ICU and non-ICU groups at both study sites. In the case of hepcidin, the levels were significantly higher in the ICU group at both study sites compared to the non-ICU group. Among the groups within each study site, the highest altitude area presented statistically significant differences between its groups in all the markers evaluated. In the lower altitude area, differences were only observed between the groups for the zinc biomarker.

conclusionCOVID-19 patients residing at high altitudes tend to have higher levels of zinc and IL-6 in all groups studied compared to their lower altitude counterparts.

Indexed as

COVID-19ferritinhepcidinIL-6zinc

Identifiers

PMID39062181
PMCPMC11275107

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