Evidence map›Paper›PMID 39062144›Full record

ArticleBiomedicines2024

Boosting Immunogenicity of a Recombinant

Shivani Singh, David Kanzin, Sarah Chavez, Noemi Alejandra Saavedra-Avila, Tony W Ng, Regy Lukose, Oren Mayer, John Kim, Bing Chen, Mei Chen and 3 more

Abstract read
In one paragraph

Article in Biomedicines, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors.

Shivani SinghDepartment of Microbiology & Immunology, Albert Einstein College of Medicine, New York, NY 10461, USA.
David KanzinDepartment of Biological Sciences and Border Biomedical Research Center, University of Texas, El Paso, TX 79968, USA.
Sarah ChavezDepartment of Biological Sciences and Border Biomedical Research Center, University of Texas, El Paso, TX 79968, USA.
Noemi Alejandra Saavedra-AvilaDepartment of Microbiology & Immunology, Albert Einstein College of Medicine, New York, NY 10461, USA.
Tony W NgDepartment of Microbiology & Immunology, Albert Einstein College of Medicine, New York, NY 10461, USA.
Regy LukoseDepartment of Microbiology & Immunology, Albert Einstein College of Medicine, New York, NY 10461, USA.
Oren MayerDepartment of Microbiology & Immunology, Albert Einstein College of Medicine, New York, NY 10461, USA.
John KimDepartment of Microbiology & Immunology, Albert Einstein College of Medicine, New York, NY 10461, USA.
Bing ChenDepartment of Microbiology & Immunology, Albert Einstein College of Medicine, New York, NY 10461, USA.
Mei ChenDepartment of Microbiology & Immunology, Albert Einstein College of Medicine, New York, NY 10461, USA.
Steven A PorcelliDepartment of Microbiology & Immunology, Albert Einstein College of Medicine, New York, NY 10461, USA.
William R JacobsDepartment of Microbiology & Immunology, Albert Einstein College of Medicine, New York, NY 10461, USA.ORCID 0000-0003-3321-3080
Sangeeta TiwariDepartment of Biological Sciences and Border Biomedical Research Center, University of Texas, El Paso, TX 79968, USA.ORCID 0000-0003-1727-8036

Funding

Precision Targeting of CD1-Restricted iNKT Cells for Cancer ImmunotherapyR01AI045889 · NIAID · YESHIVA UNIVERSITY · PI Steven A Porcelli · 1999 to 2026
$9.3M
Molecular Genetic Analysis of Mycobacterium TuberculosisR37AI026170 · NIAID · ALBERT EINSTEIN COL OF MED YESHIVA UNIV · PI WILLIAM Robert JACOBS · 2004 to 2026
$7.7M
Generation of a Complete Set of Precise Null Bar-Coded Deletion Mutants of Mycobacterium tuberculosisR24AI134650 · NIAID · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI Shazia Hamid, WILLIAM Robert JACOBS · 2017 to 2026
$5.6M
Immunoregulation by indoleamine 2,3-dioxygenases in tuberculosisR01AI137344 · NIAID · RBHS-NEW JERSEY MEDICAL SCHOOL · PI CHAN, JOHN R., PORCELLI, STEVEN A · 2018 to 2022
$4.0M
Modulation of Host Cell Environment by Mycobacterial PE/PPE ProteinsR01AI127711 · NIAID · UNIVERSITY OF TEXAS MED BR GALVESTON · PI LEE, SUNHEE, PORCELLI, STEVEN A · 2017 to 2021
$2.8M
Development of Drugs to Target Arginine Biosythesis in Mycobacterium tuberculosisSC1GM140968 · NIGMS · UNIVERSITY OF TEXAS EL PASO · PI TIWARI, SANGEETA · 2021 to 2024
$1.5M
NIAID NIH HHS R01 AI045889NIAID NIH HHS R01 AI127711NIAID NIH HHS R01 AI137344NIAID NIH HHS R24 AI134650NIAID NIH HHS R37 AI026170NIGMS NIH HHS SC1 GM140968NIH HHS 1SB1GM140968-21A12
6 · The paper itself

Abstract

Tuberculosis (TB) continues to be a major global health burden and kills over a million people annually. New immunization strategies are required for the development of an efficacious TB vaccine that can potentially induce sterilizing immunity. In this study, we first confirmed that a live vaccine strain of

Indexed as

BCGrpmb2tuberculosisvaccinezinc

Identifiers

PMID39062144
PMCPMC11274837

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.