Evidence map›Paper›PMID 39062122›Full record

ReviewBiomedicines2024

Routinely Used and Emerging Diagnostic and Immunotherapeutic Approaches for Wheat Allergy.

Wanqi Zheng, Christine Yee Yan Wai, Jason Ka Chun Sit, Nam Sze Cheng, Christy Wing Man Leung, Ting Fan Leung

Abstract readReview
In one paragraph

Review in Biomedicines, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Wanqi ZhengDepartment of Paediatrics, The Chinese University of Hong Kong, Shatin, Hong Kong.
Christine Yee Yan WaiDepartment of Paediatrics, The Chinese University of Hong Kong, Shatin, Hong Kong.
Jason Ka Chun SitDepartment of Paediatrics, The Chinese University of Hong Kong, Shatin, Hong Kong.
Nam Sze ChengDepartment of Paediatrics, The Chinese University of Hong Kong, Shatin, Hong Kong.
Christy Wing Man LeungFaculty of Medicine, The Chinese University of Hong Kong, Shatin, Hong Kong.
Ting Fan LeungDepartment of Paediatrics, The Chinese University of Hong Kong, Shatin, Hong Kong.ORCID 0000-0002-6469-1926

Funding

Health Bureau, Hong Kong SAR Government 10210336
6 · The paper itself

Abstract

Wheat, a component of the staple diet globally, is a common food allergen in children. The symptoms of wheat allergy (WA) range from skin rash to shortness of breath, significantly impairing quality of life. Following initial clinical suspicion, individuals may undergo routinely used allergy tests such as a wheat allergen-specific skin prick test (SPT), a blood test for specific immunoglobulin E (sIgE) levels, or oral food challenge. Conventional management of WA lies in wheat avoidance, yet accidental consumption may be inevitable owing to the ubiquity of wheat in various food products. This article aims to provide an overview of the immunologic pathway of WA, followed by its emerging diagnostic methods, namely alcohol-soluble SPT extracts, component-resolved diagnosis, and the basophil activation test (BAT). The mechanisms underlying wheat allergen-specific oral immunotherapy (OIT) as well as a summary of the efficacy, tolerability, and safety of related clinical trials will then be discussed.

Indexed as

component-resolved diagnosisdesensitizationimmunologyoral immunotherapywheat allergy

Identifiers

PMID39062122
PMCPMC11275021

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.