Evidence map›Paper›PMID 39062096›Full record

ArticleBiomedicines2024

Beyond Triple-Negative: High Prevalence of Quadruple-Negative Breast Cancer in African Americans.

Oluwadamilola Oladeru, Fareed Rajack, Ashwini Esnakula, Tammey J Naab, Yasmine Kanaan, Luisel Ricks-Santi

Abstract read
In one paragraph

Article in Biomedicines, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Oluwadamilola OladeruDepartment of Radiation Oncology, Mayo Clinic, Jacksonville, FL 32224, USA.
Fareed RajackDepartment of Pathology, Howard University Hospital, Washington, DC 20059, USA.ORCID 0000-0002-0302-6228
Ashwini EsnakulaDepartment of Pathology, The Ohio State University Wexner Medical Center, Columbus, OH 43210, USA.ORCID 0000-0001-6029-0124
Tammey J NaabDepartment of Pathology, Howard University Hospital, Washington, DC 20059, USA.
Yasmine KanaanDepartment of Microbiology, Howard University College of Medicine, Washington, DC 20059, USA.
Luisel Ricks-SantiDepartment of Pharmacotherapy and Translational Research, University of Florida College of Pharmacy, Gainesville, FL 32610, USA.ORCID 0000-0003-2987-9509

Funding

Functional analysis of genetic variants in African Americans with Breast CancerR15CA239100 · NCI · HAMPTON UNIVERSITY · PI MCDONALD, JOHN TYSON, RICKS-SANTI, LUISEL J. · 2019 to 2019
$444k
NCI NIH HHS R15CA239100
6 · The paper itself

Abstract

Quadruple-negative breast cancer (QNBC) is a triple-negative breast cancer (TNBC) subtype that lacks expression of the androgen (AR) receptor. Few studies have focused on this highly aggressive breast cancer, portending worse survival rates. We aimed to determine the following: (1) QNBC's molecular and clinical characteristics and compare them with other subtypes and (2) QNBC's association with clinicopathological factors and prognostic markers. We performed immunohistochemical evaluations of ARs on tissue tumor microarrays from FFPE tumor blocks of invasive ductal breast carcinomas in 202 African American women. Univariate analysis was performed using the chi-square test, with survival rates calculated using Kaplan-Meier curves. Overall, 75.8% of TNBCs were AR-negative. Compared to the luminal subtypes, TNBC and QNBC tumors were likely to be a higher grade (

Indexed as

breast cancercancer disparitiesprognostic markersquadruple-negative breast cancertriple-negative breast cancer

Identifiers

PMID39062096
PMCPMC11275194

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.