ArticleBiomedicines2024
Reduction in Xenogeneic Epitopes on Porcine Endothelial Cells by Periodate Oxidation.
Article in Biomedicines, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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8 authors.
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Abstract
backgroundPatterns of humoral immune responses represent a major hurdle in terms of pig-to-human xenotransplantation approaches. The best-known xenogeneic glycan antigens present in pigs are the αGal (Galili antigen) and the non-human sialic acid Neu5Gc. As there are further differences between porcine and human cellular surface glycosylation, a much broader range of glycan epitopes with xeno-reactive relevance can be anticipated. Therefore, we set out to chemically modify porcine cellular surface glycans in a global approach by applying sodium periodate (NaIO
methodsPorcine endothelial cells were exposed to oxidation with 1 to 5 mM NaIO
resultsTreatment of porcine endothelial cells and tissues with NaIO
conclusionsGlycan epitopes on living cells can be oxidized with NaIO
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