Evidence map›Paper›PMID 39062025›Full record

ArticleBiomedicines2024

The Hydroxypyridinone Iron Chelator DIBI Reduces Bacterial Load and Inflammation in Experimental Lung Infection.

Xiyang Zhang, Rhea Nickerson, Lauren Burton, Ashley Stueck, Bruce Holbein, Zhenyu Cheng, Juan Zhou, Christian Lehmann

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomedicines, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Xiyang ZhangDepartment of Anesthesia, Pain Management and Perioperative Medicine, Dalhousie University, Halifax, NS B3H 1X5, Canada.
Rhea NickersonDepartment of Microbiology & Immunology, Dalhousie University, Halifax, NS B3H 1X5, Canada.
Lauren BurtonDepartment of Microbiology & Immunology, Dalhousie University, Halifax, NS B3H 1X5, Canada.
Ashley StueckDepartment of Pathology, Dalhousie University, Halifax, NS B3H 1X5, Canada.ORCID 0000-0002-0328-6687
Bruce HolbeinDepartment of Microbiology & Immunology, Dalhousie University, Halifax, NS B3H 1X5, Canada.
Zhenyu ChengDepartment of Microbiology & Immunology, Dalhousie University, Halifax, NS B3H 1X5, Canada.ORCID 0000-0002-7240-9126
Juan ZhouDepartment of Anesthesia, Pain Management and Perioperative Medicine, Dalhousie University, Halifax, NS B3H 1X5, Canada.ORCID 0000-0002-3040-0238
Christian LehmannDepartment of Anesthesia, Pain Management and Perioperative Medicine, Dalhousie University, Halifax, NS B3H 1X5, Canada.ORCID 0000-0001-6419-9168

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Iron plays a critical role in lung infections due to its function in the inflammatory immune response but also as an important factor for bacterial growth. Iron chelation represents a potential therapeutic approach to inhibit bacterial growth and pathologically increased pro-inflammatory mediator production. The present study was designed to investigate the impact of the iron chelator DIBI in murine lung infection induced by intratracheal

Indexed as

inflammationiron chelationlung infectionPseudomonas aeruginosa

Identifiers

PMID39062025
PMCPMC11274704

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.