Evidence map›Paper›PMID 39062020›Full record

ArticleBiomedicines2024

Hydrogen-Rich Water (HRW) Reduces Fatty Acid-Induced Lipid Accumulation and Oxidative Stress Damage through Activating AMP-Activated Protein Kinase in HepG2 Cells.

Sing-Hua Tsou, Sheng-Chieh Lin, Wei-Jen Chen, Hui-Chih Hung, Chun-Cheng Liao, Edy Kornelius, Chien-Ning Huang, Chih-Li Lin, Yi-Sun Yang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomedicines, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Sing-Hua TsouDepartment of Medical Research, Chung Shan Medical University Hospital, Taichung 402, Taiwan.ORCID 0000-0001-7574-028X
Sheng-Chieh LinSchool of Medicine, Chung Shan Medical University, Taichung 402, Taiwan.
Wei-Jen ChenDepartment of Biomedical Sciences, Chung Shan Medical University, Taichung 402, Taiwan.ORCID 0000-0002-3729-989X
Hui-Chih HungDepartment of Life Sciences and Institute of Genomics and Bioinformatics, National Chung Hsing University, Taichung 402, Taiwan.ORCID 0000-0003-0180-1822
Chun-Cheng LiaoDepartment of Family Medicine, Taichung Armed Forces General Hospital, Taichung 411, Taiwan.ORCID 0000-0002-7508-6297
Edy KorneliusSchool of Medicine, Chung Shan Medical University, Taichung 402, Taiwan.ORCID 0000-0002-9342-5467
Chien-Ning HuangDepartment of Internal Medicine, Division of Endocrinology and Metabolism, Chung Shan Medical University Hospital, Taichung 402, Taiwan.
Chih-Li LinDepartment of Medical Research, Chung Shan Medical University Hospital, Taichung 402, Taiwan.ORCID 0000-0003-4553-3727
Yi-Sun YangSchool of Medicine, Chung Shan Medical University, Taichung 402, Taiwan.

Funding

Chung Shan Medical University Hospital CSH-2018-C-015Taichung Armed Forces General Hospital TCAFGH-A-110002the Ministry of Science and Technology of Taiwan 112-2320-B-040-003-MY3 and 111-2320-B-040-017-MY3
6 · The paper itself

Abstract

Metabolic dysfunction-associated steatotic liver disease (MASLD) is characterized by excessive fat accumulation in the liver. Intracellular oxidative stress induced by lipid accumulation leads to various hepatocellular injuries including fibrosis. However, no effective method for mitigating MASLD without substantial side effects currently exists. Molecular hydrogen (H

Indexed as

5′-AMP-activated protein kinase (AMPK)free fatty acid (FFA)hydrogen-rich water (HRW)metabolic dysfunction-associated steatotic liver disease (MASLD)oxidative stress

Identifiers

PMID39062020
PMCPMC11274623

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.