ArticleBiomedicines2024
Exposure to Volatile Organic Compounds May Contribute to Atopic Dermatitis in Adults.
Article in Biomedicines, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- Short-term effects and attributable burden of ambient volatile organic compound mixtures on pediatric atopic dermatitis and asthma in Seoul.Journal of exposure science & environmental epidemiology · 2026Article
- Clinically actionable classification tool for childhood and adult atopic dermatitis via explainable AI: a retrospective cross-sectional study optimizing diagnostic accuracy.BioData mining · 2026Article
- Integrative transcriptomic analysis identifies CCL22-associated immune signatures in air pollution-related atopic dermatitis.Frontiers in public health · 2026Article
- Differentiating superficial fungal infection from eczema using a heated dynamic-headspace skin VOC sampler: a hypothesis.Frontiers in medicine · 2026Article
- The Role of Air Pollution in the Pathogenesis of Atopic Dermatitis, With a Focus on Oxidative Stress.Clinical and translational allergy · 2025Review
- A review of pharmaceutical and personal care products and atopic dermatitis based on epidemiological and basic research findings.Frontiers in public health · 2025Review
- Changes in Gene Expression Related to Atopic Dermatitis in Mothers and Infants Following VOC Exposure.International journal of molecular sciences · 2024Article
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Authors and funding
7 authors.
Funding
Abstract
backgroundVolatile organic compounds (VOC) are major indoor air pollutants. Previous studies reported an association between VOC exposure and allergic diseases. Here, we aimed to explore the relationship between VOC exposure and atopic dermatitis (AD) in adults.
methodsWe prospectively enrolled 31 adult AD patients and 11 healthy subjects as controls. Urine metabolite levels of VOCs, including 1.3-butadiene, acrylamide, benzene, toluene, and xylene, were all determined with liquid chromatography-mass spectrometry. The relationship between AD and log-transformed urine levels of VOC metabolites were examined using a multivariate linear regression model adjusted for age and sex. We also treated mouse bone marrow-derived cells (BMMCs) with 1,3-butadiene and toluene and measured the release of β-hexosaminidase.
resultsOur results demonstrated that creatinine-corrected urine levels of N-Acetyl-S- (3,4-dihydroxybutyl)-L-cysteine (DHBMA), N-Acetyl-S-(2-carbamoyl-2-hydroxyethyl)-L-cysteine (GAMA), and N-Acetyl-S-(benzyl)-L-cysteine (BMA) were all elevated in AD patients compared with controls. In a multivariate linear regression model, creatinine-corrected urine levels of BMA (a toluene metabolite) and DHBMA (a 1,3-butadiene metabolite) appeared elevated in AD patients, although statistical significance was not reached after correction for multiple comparisons. In addition, 1,3-butadiene and toluene could stimulate BMMCs to degranulate as much as compound 48/80.
conclusionsSome VOCs, such as 1,3-butadiene and toluene, might be associated with AD pathogenesis in adults.
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