Evidence map›Paper›PMID 39061958›Full record

ReviewBiomedicines2024

Genomic Profiling for Predictive Treatment Strategies in Fibrotic Interstitial Lung Disease.

Fabio Perrotta, Stefano Sanduzzi Zamparelli, Vito D'Agnano, Antonia Montella, Ramona Fomez, Raffaella Pagliaro, Angela Schiattarella, Mario Cazzola, Andrea Bianco, Domenica Francesca Mariniello

Abstract readReview
In one paragraph

Review in Biomedicines, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Fabio PerrottaDepartment of Translational Medical Sciences, University of Campania "L. Vanvitelli", 80131 Naples, Italy.
Stefano Sanduzzi ZamparelliDivision of Pneumology, A. Cardarelli Hospital, 80128 Naples, Italy.ORCID 0000-0003-3336-7290
Vito D'AgnanoDepartment of Translational Medical Sciences, University of Campania "L. Vanvitelli", 80131 Naples, Italy.ORCID 0000-0001-6742-9387
Antonia MontellaDepartment of Translational Medical Sciences, University of Campania "L. Vanvitelli", 80131 Naples, Italy.
Ramona FomezDepartment of Translational Medical Sciences, University of Campania "L. Vanvitelli", 80131 Naples, Italy.
Raffaella PagliaroDepartment of Translational Medical Sciences, University of Campania "L. Vanvitelli", 80131 Naples, Italy.ORCID 0009-0006-2902-3558
Angela SchiattarellaDepartment of Translational Medical Sciences, University of Campania "L. Vanvitelli", 80131 Naples, Italy.
Mario CazzolaUnit of Respiratory Medicine, Department of Experimental Medicine, University of Rome "Tor Vergata", 00133 Rome, Italy.ORCID 0000-0003-4895-9707
Andrea BiancoDepartment of Translational Medical Sciences, University of Campania "L. Vanvitelli", 80131 Naples, Italy.ORCID 0000-0002-4692-5901
Domenica Francesca MarinielloUOC Pneumotisiologia Federico II, A.O.R.N. Monaldi-Cotugno-CTO Piazzale Ettore Ruggieri, 80131 Napoli, Italy.ORCID 0000-0003-2932-3164

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Idiopathic pulmonary fibrosis (IPF) has traditionally been considered the archetype of progressive fibrotic interstitial lung diseases (f-ILDs), but several other f-ILDs can also manifest a progressive phenotype. Integrating genomic signatures into clinical practice for f-ILD patients may help to identify patients predisposed to a progressive phenotype. In addition to the risk of progressive pulmonary fibrosis, there is a growing body of literature examining how pharmacogenomics influences treatment response, particularly regarding the efficacy and safety profiles of antifibrotic and immunomodulatory agents. In this narrative review, we discuss current studies in IPF and other forms of pulmonary fibrosis, including systemic autoimmune disorders associated ILDs, sarcoidosis and hypersensitivity pneumonitis. We also provide insights into the future direction of research in this complex field.

Indexed as

antifibroticsidiopathic pulmonary fibrosisinterstitial lung diseasesnintedanibpharmacogenomicspirfenidoneprecision medicine

Identifiers

PMID39061958
PMCPMC11274143

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.