Evidence map›Paper›PMID 39061943›Full record

ArticleAntioxidants (Basel, Switzerland)2024

Rod-Shaped Mesoporous Zinc-Containing Bioactive Glass Nanoparticles: Structural, Physico-Chemical, Antioxidant, and Immuno-Regulation Properties.

Xiuan Zhu, Wenjie Wen, Jingjing Yan, Yuran Wang, Rumeng Wang, Xiang Ma, Dandan Ren, Kai Zheng, Chao Deng, Jue Zhang

Abstract read
In one paragraph

Article in Antioxidants (Basel, Switzerland), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Article
  2. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Xiuan ZhuAnhui Province Engineering Research Center for Dental Materials and Application, School of Stomatology, Binjiang Campus, Wannan Medical College, No. 22, West Wenchang Road, Yijiang District, Wuhu 241002, China.
Wenjie WenAnhui Province Engineering Research Center for Dental Materials and Application, School of Stomatology, Binjiang Campus, Wannan Medical College, No. 22, West Wenchang Road, Yijiang District, Wuhu 241002, China.
Jingjing YanAnhui Province Engineering Research Center for Dental Materials and Application, School of Stomatology, Binjiang Campus, Wannan Medical College, No. 22, West Wenchang Road, Yijiang District, Wuhu 241002, China.
Yuran WangAnhui Province Engineering Research Center for Dental Materials and Application, School of Stomatology, Binjiang Campus, Wannan Medical College, No. 22, West Wenchang Road, Yijiang District, Wuhu 241002, China.
Rumeng WangAnhui Province Engineering Research Center for Dental Materials and Application, School of Stomatology, Binjiang Campus, Wannan Medical College, No. 22, West Wenchang Road, Yijiang District, Wuhu 241002, China.
Xiang MaAnhui Province Engineering Research Center for Dental Materials and Application, School of Stomatology, Binjiang Campus, Wannan Medical College, No. 22, West Wenchang Road, Yijiang District, Wuhu 241002, China.
Dandan RenAnhui Province Engineering Research Center for Dental Materials and Application, School of Stomatology, Binjiang Campus, Wannan Medical College, No. 22, West Wenchang Road, Yijiang District, Wuhu 241002, China.
Kai ZhengJiangsu Province Engineering Research Center of Stomatological Translational Medicine, Nanjing Medical University, Nanjing 210029, China.ORCID 0000-0002-2573-6677
Chao DengAnhui Province Engineering Research Center for Dental Materials and Application, School of Stomatology, Binjiang Campus, Wannan Medical College, No. 22, West Wenchang Road, Yijiang District, Wuhu 241002, China.
Jue ZhangAnhui Province Engineering Research Center for Dental Materials and Application, School of Stomatology, Binjiang Campus, Wannan Medical College, No. 22, West Wenchang Road, Yijiang District, Wuhu 241002, China.

Funding

Applied Basic Research Project of Wuhu Science and Technology Bureau 2022jc29Natural Science Key project of Anhui Education Department 2022AH051227Natural Science Key project of Anhui Education Department Natural Science Key project of Anhui Education DepartmentProgram for Excellent Sci-tech Innovation Teams of Universities in Anhui Province 2023AH010073
6 · The paper itself

Abstract

Bioactive glass nanoparticles (BGNs) are applied widely in tissue regeneration. Varied micro/nanostructures and components of BGNs have been designed for different applications. In the present study, nanorod-shaped mesoporous zinc-containing bioactive glass nanoparticles (ZnRBGNs) were designed and developed to form the bioactive content of composite materials for hard/soft tissue repair and regeneration. The nanostructure and components of the ZnRBGNs were characterized, as were their cytocompatibility and radical-scavenging activity in the presence/absence of cells and their ability to modulate macrophage polarization. The ZnRBGNs possessed a uniform rod shape (length ≈ 500 nm; width ≈ 150 nm) with a mesoporous structure (diameter ≈ 2.4 nm). The leaching liquid of the nanorods at a concentration below 0.5 mg/mL resulted in no cytotoxicity. More significant improvements in the antioxidant and M1-polarization-inhibiting effects and the promotion of M2 polarization were found when culturing the cells with the ZnRBGNs compared to when culturing them with the RBGNs. The doping of the Zn element in RBGNs may lead to improved antioxidant and anti-inflammatory effects, which may be beneficial in tissue regeneration/repair.

Indexed as

bioactive glassmacrophage polarizationradical-scavenging activityrod-shaped nanoparticles

Identifiers

PMID39061943
PMCPMC11274306

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.