Evidence map›Paper›PMID 39061904›Full record

ArticleAntioxidants (Basel, Switzerland)2024

NHE1 Protein in Repetitive Mild TBI-Mediated Neuroinflammation and Neurological Function Impairment.

John P Bielanin, Shamseldin A H Metwally, Helena C M Oft, Satya S Paruchuri, Lin Lin, Okan Capuk, Nicholas D Pennock, Shanshan Song, Dandan Sun

Abstract read
In one paragraph

Article in Antioxidants (Basel, Switzerland), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

John P BielaninDepartment of Neurology, University of Pittsburgh, Pittsburgh, PA 15213, USA.
Shamseldin A H MetwallyDepartment of Neurology, University of Pittsburgh, Pittsburgh, PA 15213, USA.ORCID 0000-0002-3819-6665
Helena C M OftDepartment of Neurology, University of Pittsburgh, Pittsburgh, PA 15213, USA.
Satya S ParuchuriDepartment of Neurology, University of Pittsburgh, Pittsburgh, PA 15213, USA.
Lin LinDepartment of Neurology, University of Pittsburgh, Pittsburgh, PA 15213, USA.
Okan CapukDepartment of Neurology, University of Pittsburgh, Pittsburgh, PA 15213, USA.
Nicholas D PennockDepartment of Neurology, University of Pittsburgh, Pittsburgh, PA 15213, USA.
Shanshan SongDepartment of Neurology, University of Pittsburgh, Pittsburgh, PA 15213, USA.ORCID 0000-0002-7200-5922
Dandan SunDepartment of Neurology, University of Pittsburgh, Pittsburgh, PA 15213, USA.

Funding

Medical Scientist Training ProgramT32GM144300 · NIGMS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI RICHARD A STEINMAN, Russell S Schwartz · 2022 to 2026
$7.9M
Microglia in White Matter Repair after TBII01BX004625 · VA · VETERANS HEALTH ADMINISTRATION · PI SUN, DANDAN · 2020 to 2024
–
BLRD VA I01 BX004625BLRD VA I01 BX006372BLRD VA IK6 BX005647Career Research Scientist Award IK6BX005647NIGMS NIH HHS T32 GM144300Veterans Affairs Merit Award I01 BX006372-01
6 · The paper itself

Abstract

Mild traumatic brain injuries (mTBIs) are highly prevalent and can lead to chronic behavioral and cognitive deficits often associated with the development of neurodegenerative diseases. Oxidative stress and formation of reactive oxygen species (ROS) have been implicated in mTBI-mediated axonal injury and pathogenesis. However, the underlying mechanisms and contributing factors are not completely understood. In this study, we explore these pathogenic mechanisms utilizing a murine model of repetitive mTBI (r-mTBI) involving five closed-skull concussions in young adult C57BL/6J mice. We observed a significant elevation of Na

Indexed as

concussiondiffuse axonal injuryneuroinflammationoxidative stresswhite matter injury

Identifiers

PMID39061904
PMCPMC11274226

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.